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关于一种形态(形态发生动力学规律)的信息。

Information about a form (on the dynamic laws of morphogenesis).

作者信息

Beloussov Lev V, Grabovsky Vassily I

机构信息

Department of Embryology, Faculty of Biology, Moscow State University, Moscow 119899, Russia.

出版信息

Biosystems. 2007 Feb;87(2-3):204-14. doi: 10.1016/j.biosystems.2006.09.015. Epub 2006 Sep 9.

Abstract

How a developing embryo becomes "informed" about its form?" This problem remains obscure and controversial. We argue that the "information about a form" is distributed throughout three main components: the dynamic laws, the parameters and the initial/boundary conditions. In the absence of a dynamic law two other components are "blind", that is, do not contain any unambiguous information. We present a version of a dynamic law of morphogenesis, based upon the presumption of a feedback between passive and active mechanical stresses. We explore several models of shape formation based upon this law and show that, as depending upon the parameters values, they generate a large set of realistic shapes. Genetic and epigenetic basis of the models parameters is discussed.

摘要

一个发育中的胚胎是如何“知晓”其形态的?这个问题仍然晦涩且存在争议。我们认为“关于形态的信息”分布在三个主要成分中:动力学定律、参数以及初始/边界条件。如果没有动力学定律,其他两个成分就是“盲目的”,也就是说,不包含任何明确的信息。我们基于被动和主动机械应力之间反馈的假设,提出了一个形态发生的动力学定律版本。我们探索了基于该定律的几种形状形成模型,并表明,根据参数值的不同,它们能生成大量逼真的形状。文中还讨论了模型参数的遗传和表观遗传基础。

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