Sugahara T, Korogi Y, Kochi M, Ikushima I, Hirai T, Okuda T, Shigematsu Y, Liang L, Ge Y, Ushio Y, Takahashi M
Department of Radiology, Kumamoto University School of Medicine, Honjo, Japan.
AJR Am J Roentgenol. 1998 Dec;171(6):1479-86. doi: 10.2214/ajr.171.6.9843274.
Our purpose was to evaluate the relationships between the ratio of maximum relative cerebral blood volume (rCBV) (rCBV ratio = rCBV[tumor]/rCBV[contralateral white matter]) and histologic and angiographic vascularities of gliomas using the gradient-echo echoplanar MR imaging technique. We also evaluated the usefulness of rCBV maps for grading gliomas.
We examined 30 patients with histologically verified gliomas. Gliomas were classified as glioblastoma, anaplastic glioma with enhancement, anaplastic glioma without enhancement, and low-grade glioma. The maximum rCBV ratio of each glioma was compared with both histologic and angiographic vascularities, and the relationship between the maximum rCBV ratios and each type of glioma was established.
The maximum rCBV ratios of the gliomas significantly correlated with both histologic and angiographic vascularities (p < .001). Mean values and SDs of maximum rCBV ratios of each type of tumor were 7.32+/-4.39 for glioblastomas, 5.84+/-1.82 for anaplastic gliomas with enhancement, 1.53+/-0.75 for anaplastic gliomas without enhancement, and 1.26+/-0.55 for low-grade gliomas. The maximum rCBV ratios of the glioblastomas were significantly higher than those of the anaplastic gliomas without enhancement (p = .002) and the low-grade gliomas (p < .001). The maximum rCBV ratios of the anaplastic gliomas with enhancement were higher than those of the anaplastic gliomas without enhancement and the low-grade gliomas, but the differences were not statistically significant (p = .08 and p = .03, respectively).
The results of perfusion-sensitive MR imaging with gradient-echo echoplanar technique correlated with both histologic and angiographic vascularities.
我们的目的是使用梯度回波平面磁共振成像技术评估最大相对脑血容量（rCBV）比值（rCBV比值 = rCBV[肿瘤]/rCBV[对侧白质]）与胶质瘤的组织学和血管造影血管密度之间的关系。我们还评估了rCBV图在胶质瘤分级中的实用性。
我们检查了30例经组织学证实的胶质瘤患者。胶质瘤分为胶质母细胞瘤、强化型间变性胶质瘤、非强化型间变性胶质瘤和低级别胶质瘤。将每个胶质瘤的最大rCBV比值与组织学和血管造影血管密度进行比较，并建立最大rCBV比值与每种类型胶质瘤之间的关系。
胶质瘤的最大rCBV比值与组织学和血管造影血管密度均显著相关（p <.001）。每种肿瘤类型的最大rCBV比值的平均值和标准差分别为：胶质母细胞瘤7.32±4.39，强化型间变性胶质瘤5.84±1.82，非强化型间变性胶质瘤1.53±0.75，低级别胶质瘤1.26±0.55。胶质母细胞瘤的最大rCBV比值显著高于非强化型间变性胶质瘤（p =.002）和低级别胶质瘤（p <.001）。强化型间变性胶质瘤的最大rCBV比值高于非强化型间变性胶质瘤和低级别胶质瘤，但差异无统计学意义（分别为p =.08和p =.03）。
梯度回波平面技术灌注敏感磁共振成像的结果与组织学和血管造影血管密度相关。
