Hernandez-Maraver Dolores, Hernandez-Navarro Fernando, Gomez-Leon Nieves, Coya Juan, Rodriguez-Vigil Beatriz, Madero Rosario, Pinilla Immaculada, Martin-Curto Luis M
Department of Haematology, La Paz University Hospital, Madrid, Spain.
Br J Haematol. 2006 Nov;135(3):293-302. doi: 10.1111/j.1365-2141.2006.06284.x.
An accurate initial staging of patients with non-Hodgkin lymphoma (NHL) and Hodgkin lymphoma (HL) is critical for the selection of an appropriate treatment. Computed tomography (CT) remains the standard imaging technique, although it is based on anatomic criteria. Positron emission tomography (PET) with 2-deoxy-2-[fluorine-18]fluoro-d-glucose (FDG) provides useful functional information but requires anatomical correlation to localise lesions accurately. We have prospectively compared the accuracy of combined PET/CT with that of CT and PET alone at initial staging in lymphoma patients. Forty-seven newly diagnosed patients were evaluated. PET/CT was superior compared with CT and PET in nodal evaluation and detection of extranodal disease. Using a staging algorithm with PET/CT resulted in the disease stage being increased in 11 of 47 patients (10 NHL and 1 HL) (McNemar test P = 0.012). Therefore, a different treatment strategy based on PET/CT findings was suggested for seven patients (14.8%). PET/CT markedly improves accuracy in the diagnostic work-up of patients with lymphoma.
对于非霍奇金淋巴瘤（NHL）和霍奇金淋巴瘤（HL）患者，准确的初始分期对于选择合适的治疗方法至关重要。计算机断层扫描（CT）仍然是标准的成像技术，尽管它基于解剖学标准。使用2-脱氧-2-[氟-18]氟-D-葡萄糖（FDG）的正电子发射断层扫描（PET）可提供有用的功能信息，但需要与解剖结构相关联以准确定位病变。我们前瞻性地比较了淋巴瘤患者初始分期时PET/CT联合检查与单独CT和PET检查的准确性。对47例新诊断的患者进行了评估。在淋巴结评估和结外疾病检测方面，PET/CT优于CT和PET。使用基于PET/CT的分期算法，47例患者中有11例（10例NHL和1例HL）疾病分期升高（麦克内马尔检验P = 0.012）。因此，建议对7例患者（14.8%）根据PET/CT结果采用不同的治疗策略。PET/CT显著提高了淋巴瘤患者诊断检查的准确性。
