Dogliotti Eugenia
Dipartimento di Ambiente e Connessa Prevenzione Primaria, Istituto Superiore di Sanità, Rome, Italy.
Ann Ist Super Sanita. 2006;42(2):163-9.
In 1974 vinyl chloride (VC), a gas used in the plastics industry, was shown to be a human carcinogen, inducing a very rare type of tumor, angiosarcoma of the liver. The same type of tumor was induced in rodents exposed to VC thus providing an excellent model for mechanistic studies. Here, we review the numerous studies on the mechanism of action of VC with particular emphasis on the DNA products induced by this strong alkylating agent. In particular, the genotoxicity, repair mechanisms, in vivo formation and tumor mutation spectra by etheno-adducts will be analysed and possible approaches for future research suggested.
1974年，塑料工业中使用的气体氯乙烯（VC）被证明是一种人类致癌物，可诱发一种非常罕见的肿瘤——肝血管肉瘤。在接触VC的啮齿动物中也诱发了相同类型的肿瘤，从而为机制研究提供了一个极好的模型。在此，我们综述了关于VC作用机制的大量研究，特别强调了这种强烷化剂诱导产生的DNA产物。具体而言，将分析乙烯基加合物的遗传毒性、修复机制、体内形成以及肿瘤突变谱，并提出未来研究的可能方法。
