Oushani Negar Hajimohammadi, Valipour Masoumeh, Maghami Parvaneh
Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran.
Department of Biology, Faculty of Basic Science, Azarbaijan Shahid Madani University, Tabriz, Iran.
Toxicol Res. 2022 Jun 25;38(4):557-566. doi: 10.1007/s43188-022-00137-1. eCollection 2022 Oct.
Vinyl chloride is a colorless gas with a pleasant odor capable of entering the body through oral or inhalation routes. Extensive studies on this compound indicated that it is a carcinogen, and Vinyl chloride exposure can result in a specific type of cancer in vinyl chloride workers. Whereas hemoglobin plays a vital role in oxygen transfer throughout the body, in a molecular aspect, the effect of vinyl chloride on human hemoglobin has not been studied. Furthermore, selenium as an antioxidant is a vital factor for the health of humans and animals. Then this research investigated the effect of the antioxidant capability of selenium at the same concentrations in blood on the interaction between vinyl chloride and hemoglobin. UV-visible, Fourier-transform infrared, chemiluminescence, and fluorescence spectroscopies were employed. The results indicated the destruction of hemoglobin structure in different concentrations of vinyl chloride. At the same time, the antioxidant effect of selenium inhibited the destructive impact of vinyl chloride on hemoglobin structure.
氯乙烯是一种无色气体，具有宜人的气味，能够通过口服或吸入途径进入人体。对该化合物的广泛研究表明它是一种致癌物，接触氯乙烯会导致氯乙烯工人患特定类型的癌症。虽然血红蛋白在全身的氧气输送中起着至关重要的作用，但在分子层面，氯乙烯对人类血红蛋白的影响尚未得到研究。此外，作为抗氧化剂的硒是人类和动物健康的重要因素。因此，本研究调查了相同浓度血液中硒的抗氧化能力对氯乙烯与血红蛋白之间相互作用的影响。采用了紫外可见光谱、傅里叶变换红外光谱、化学发光光谱和荧光光谱。结果表明不同浓度的氯乙烯会破坏血红蛋白结构。同时，硒的抗氧化作用抑制了氯乙烯对血红蛋白结构的破坏作用。
