Roé E, Dalmau J, García-Navarro X, Corella F, Monfort D, Busquets D, Ribé A, Delgado E, Alomar A
Department of Dermatology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
Dermatology. 2006;213(3):234-5. doi: 10.1159/000095042.
Pyoderma gangrenosum is a reactive inflammatory dermatosis which belongs to the spectrum of neutrophilic dermatoses. Due to a lack of diagnostic criteria, pyoderma gangrenosum is mainly a diagnosis of exclusion. It is rarely observed on the perineum, and vulvar involvement is even less frequent. Collagenous colitis is an idiopathic inflammatory colonic disease that is included in the microscopic colitides. The colonic mucosa and the crypt architecture are preserved but histologic alterations are found. We describe a case of collagenous colitis associated with vulvar pyoderma gangrenosum that improved spectacularly with cyclosporine 3 mg/kg/day and the twice-daily application of topical tacrolimus 0.1%.
坏疽性脓皮病是一种反应性炎症性皮肤病，属于嗜中性皮病范畴。由于缺乏诊断标准，坏疽性脓皮病主要是一种排除性诊断。它很少出现在会阴部位，累及外阴的情况更为罕见。胶原性结肠炎是一种特发性炎症性结肠疾病，属于微观性结肠炎。结肠黏膜和隐窝结构得以保留，但存在组织学改变。我们报告一例胶原性结肠炎合并外阴坏疽性脓皮病的病例，该病例经每日3毫克/千克环孢素及每日两次外用0.1%他克莫司治疗后显著改善。
