Fasching Peter A, von Minckwitz Gunter, Fischer Thorsten, Kaufmann Manfred, Schultz-Zehden Beate, Beck Heike, Lux Michael P, Jacobs Volker, Meden Harald, Kiechle Marion, Beckmann Matthias W, Paepke Stefan
Department of Gynecology and Obstetrics, Erlangen University Hospital, Universitaetsstrasse 21-23, D-91054, Erlangen, Germany.
Breast Cancer Res Treat. 2007 Jan;101(1):95-104. doi: 10.1007/s10549-006-9272-2. Epub 2006 Oct 11.
To find associations between knowledge about risk factors for breast cancer and the socioeconomic status of healthy women, as well as their attitude toward taking chemopreventive drugs.
Between April and September 1999, 7135 healthy women completed questionnaires providing information about their willingness to take chemopreventive drugs. Items in the questionnaire included the sources of the information they had, their estimates of the population and personal lifetime risk, and risk factors for breast cancer.
A total of 6597 questionnaires were evaluable. The responders' median age was 44. Fifty-five percent of the women were willing to consider receiving chemopreventive drugs to lower their risk for breast cancer. Participants who estimated the population risk as being very high were more disposed to receive chemoprevention (65.3%), as were women who estimated their own breast cancer risk as being high (74.1%). A family history of breast cancer only had a low impact on willingness to receive chemoprevention. Women with a family history of breast cancer were willing to take chemopreventive agents in 57.2% of cases. The multivariate analysis showed that knowing about risk factors and having a lower educational level were factors positively correlated with willingness to consider chemoprevention.
These findings emphasize the role of estimations of the risk of breast cancer for patients considering whether to accept chemoprevention treatment. To date, only a few modern models of risk estimation have been evaluated in relation to chemoprevention. There is a need for better integration of professional risk estimations into clinical practice.
探寻健康女性对乳腺癌危险因素的认知与社会经济地位之间的关联，以及她们对服用化学预防药物的态度。
1999年4月至9月期间，7135名健康女性完成了问卷调查，提供了有关她们服用化学预防药物意愿的信息。问卷中的项目包括她们获取信息的来源、对人群及个人终身风险的估计，以及乳腺癌的危险因素。
共有6597份问卷可进行评估。应答者的年龄中位数为44岁。55%的女性愿意考虑接受化学预防药物以降低患乳腺癌的风险。估计人群风险非常高的参与者更倾向于接受化学预防（65.3%），估计自身患乳腺癌风险高的女性也是如此（74.1%）。乳腺癌家族史对接受化学预防的意愿影响较小。有乳腺癌家族史的女性在57.2%的情况下愿意服用化学预防药物。多因素分析表明，了解危险因素和教育水平较低是与考虑化学预防意愿呈正相关的因素。
这些发现强调了乳腺癌风险估计在患者考虑是否接受化学预防治疗中的作用。迄今为止，仅有少数现代风险估计模型针对化学预防进行了评估。有必要将专业的风险估计更好地整合到临床实践中。
