Nam Ju-Suk, Turcotte Taryn J, Yoon Jeong Kyo
Center for Molecular Medicine, Maine Medical Center Research Institute, 81 Research Drive, Scarborough, ME 04074, USA.
Gene Expr Patterns. 2007 Jan;7(3):306-12. doi: 10.1016/j.modgep.2006.08.006. Epub 2006 Aug 30.
R-spondins (Rspo) are a recently discovered secretory protein family with four members in human and mouse. We and others demonstrated that R-spondins can activate canonical Wnt signaling and beta-catenin-dependent gene expression. Our study further demonstrated that R-spondins are novel ligands for the Frizzled8 and LRP6 (LDL-receptor-related protein 6) receptors. To gain insight into their biological functions, the RNA expression pattern of the mouse R-spondin family genes was analyzed during mouse development. Our study shows that R-spondin gene transcripts are widely expressed with distinct patterns in mouse at different developmental stages.
R- 应答蛋白（Rspo）是最近发现的一个分泌蛋白家族，在人类和小鼠中各有四个成员。我们和其他研究人员证明，R- 应答蛋白可以激活经典 Wnt 信号通路以及 β- 连环蛋白依赖性基因表达。我们的研究进一步证明，R- 应答蛋白是卷曲蛋白 8（Frizzled8）和低密度脂蛋白受体相关蛋白 6（LRP6）受体的新型配体。为深入了解它们的生物学功能，我们分析了小鼠发育过程中 R- 应答蛋白家族基因的 RNA 表达模式。我们的研究表明，R- 应答蛋白基因转录本在小鼠不同发育阶段广泛表达，且模式各异。
