正常巨噬细胞和卡介苗激活的巨噬细胞对小鼠淋巴瘤体外生长的差异刺激作用
Differential stimulation of murine lymphoma growth in vitro by normal and BCG-activated macrophages.
作者信息
Nathan C F, Terry W D
出版信息
J Exp Med. 1975 Oct 1;142(4):887-902. doi: 10.1084/jem.142.4.887.
Abstract
Peritoneal macrophages from mice infected with Bacille Calmette-Guérin (BCG) and from normal mice were examined for their effects in vitro on thymidine uptake by 10 murine lymphomas, a murine fibroblast line, and a guinea pig hepatoma. Only the murine fibroblast line showed growth inhibition in the presence of BCG macrophages. For the majority of tumors, normal macrophages were profoundly stimulatory to tumor cell DNA synthesis, while BCG macrophages were much less stimulatory, without being frankly inhibitory. The effect of 2-mercaptoethanol on tumor cell growth was also studied. All lymphomas stimulated to grow more rapidly in vitro by normal macrophages were stimulated to a similar degree by 2-mercaptoethanol.
摘要
研究了感染卡介苗（BCG）的小鼠和正常小鼠的腹腔巨噬细胞在体外对10种鼠淋巴瘤、1种鼠成纤维细胞系和1种豚鼠肝癌细胞摄取胸苷的影响。只有鼠成纤维细胞系在存在卡介苗巨噬细胞的情况下表现出生长抑制。对于大多数肿瘤，正常巨噬细胞对肿瘤细胞DNA合成有显著的刺激作用，而卡介苗巨噬细胞的刺激作用则小得多，且无明显抑制作用。还研究了2-巯基乙醇对肿瘤细胞生长的影响。所有在体外被正常巨噬细胞刺激而生长更快的淋巴瘤，也被2-巯基乙醇刺激到类似程度。
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本文引用的文献
1
HOMOGRAFT TARGET CELLS: SPECIFIC DESTRUCTION IN VITRO BY CONTACT INTERACTION WITH IMMUNE MACROPHAGES.同种移植靶细胞：通过与免疫巨噬细胞的接触相互作用在体外特异性破坏
Science. 1964 Sep 25;145(3639):1427-9. doi: 10.1126/science.145.3639.1427.
2
Effect of BCG infection on leukemia and polyoma in mice and hamsters.
Proc Soc Exp Biol Med. 1962 Dec;111:739-42. doi: 10.3181/00379727-111-27908.
3
4
Activation of human blood monocytes by products of sensitized lymphocytes.致敏淋巴细胞产物对人血单核细胞的激活作用。
J Clin Invest. 1974 Feb;53(2):559-64. doi: 10.1172/JCI107590.
5
[Non specific active immunotherapy by B.C.G. in virus induced leukemia in E male G2 mice in isogenic receiptients].
Rev Fr Etud Clin Biol. 1967 Nov;12(9):912-4.
6
Alterations of macrophage functions by mediators from lymphocytes.淋巴细胞分泌的介质对巨噬细胞功能的影响。
J Exp Med. 1971 Jun 1;133(6):1356-76. doi: 10.1084/jem.133.6.1356.
7
Cytochemical identification of monocytes and granulocytes.单核细胞和粒细胞的细胞化学鉴定。
Am J Clin Pathol. 1971 Mar;55(3):283-90. doi: 10.1093/ajcp/55.3.283.
8
Cooperation of immune lymphoid cells with macrophages in tumour immunity.免疫淋巴细胞与巨噬细胞在肿瘤免疫中的协同作用。
Nature. 1970 Nov 14;228(5272):620-2. doi: 10.1038/228620a0.
9
Endotoxin and double stranded RNA render macrophages cytotoxic.内毒素和双链RNA可使巨噬细胞具有细胞毒性。
Nat New Biol. 1971 Jul 21;232(29):76-8. doi: 10.1038/newbio232076a0.
10
Immune response restoration with macrophage culture supernatants.巨噬细胞培养上清液恢复免疫反应。
Science. 1971 Jun 4;172(3987):1047-8. doi: 10.1126/science.172.3987.1047.
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