调控癌症中细胞应激免疫监视的机制。
Mechanisms regulating immune surveillance of cellular stress in cancer.
机构信息
Department of Pathology, University of California, 9500 Gilman Dr MC 0612, La Jolla, CA, 92093-0612, USA.
出版信息
Cell Mol Life Sci. 2018 Jan;75(2):225-240. doi: 10.1007/s00018-017-2597-7. Epub 2017 Jul 25.
Abstract
The purpose of this review is to explore immune-mediated mechanisms of stress surveillance in cancer, with particular emphasis on the idea that all cancers have classical hallmarks (Hanahan and Weinberg in Cell 100:57-70, 67; Cell 144:646-674, 68) that could be interrelated. We postulate that hallmarks of cancer associated with cellular stress pathways (Luo et al. in Cell 136:823-837, 101) including oxidative stress, proteotoxic stress, mitotic stress, DNA damage, and metabolic stress could define and modulate the inflammatory component of cancer. As such, the overarching goal of this review is to define the types of cellular stress that cancer cells undergo, and then to explore mechanisms by which immune cells recognize, respond to, and are affected by each stress response.
摘要
本文旨在探讨癌症中应激监视的免疫介导机制，特别强调所有癌症都具有经典特征（Hanahan 和 Weinberg，Cell 100:57-70, 67; Cell 144:646-674, 68），这些特征可能相互关联。我们假设与细胞应激途径相关的癌症特征（Luo 等人，Cell 136:823-837, 101），包括氧化应激、蛋白毒性应激、有丝分裂应激、DNA 损伤和代谢应激，可以定义并调节癌症的炎症成分。因此，本综述的首要目标是确定癌细胞经历的细胞应激类型，然后探讨免疫细胞识别、响应和受每种应激反应影响的机制。
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