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World J Gastroenterol. 2006 Oct 14;12(38):6235-8. doi: 10.3748/wjg.v12.i38.6235.
2
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Sarcoidosis during infliximab therapy for Crohn's disease.英夫利昔单抗治疗克罗恩病时并发结节病。
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本文引用的文献

1
Acute coronary syndrome after infliximab infusion.英夫利昔单抗输注后急性冠状动脉综合征
Cardiol Rev. 2006 Jan-Feb;14(1):50-2. doi: 10.1097/01.crd.0000178320.51474.ac.
2
Therapy insight: Vascular complications in patients with inflammatory bowel disease.治疗洞察：炎症性肠病患者的血管并发症
Nat Clin Pract Gastroenterol Hepatol. 2005 Jun;2(6):266-72. doi: 10.1038/ncpgasthep0190.
3
Plasma fibrinogen level and the risk of major cardiovascular diseases and nonvascular mortality: an individual participant meta-analysis.血浆纤维蛋白原水平与主要心血管疾病及非血管性死亡风险：一项个体参与者荟萃分析。
JAMA. 2005 Oct 12;294(14):1799-809. doi: 10.1001/jama.294.14.1799.
4
Effect of anti TNFalpha therapy on arterial diameter and wall shear stress and HDL cholesterol.抗TNFα治疗对动脉直径、壁面剪应力和高密度脂蛋白胆固醇的影响。
Atherosclerosis. 2004 Nov;177(1):113-8. doi: 10.1016/j.atherosclerosis.2004.04.031.
5
Extensive forearm deep venous thrombosis following a severe infliximab infusion reaction.英夫利昔单抗严重输注反应后出现广泛的前臂深静脉血栓形成。
Eur J Gastroenterol Hepatol. 2004 Sep;16(9):941-2. doi: 10.1097/00042737-200409000-00022.
6
Infliximab in inflammatory bowel disease: clinical outcome in a population based cohort from Stockholm County.英夫利昔单抗治疗炎症性肠病：来自斯德哥尔摩县基于人群队列的临床结果
Gut. 2004 Jun;53(6):849-53. doi: 10.1136/gut.2003.018515.
7
The safety profile of infliximab in patients with Crohn's disease: the Mayo clinic experience in 500 patients.英夫利昔单抗在克罗恩病患者中的安全性概况：梅奥诊所500例患者的经验
Gastroenterology. 2004 Jan;126(1):19-31. doi: 10.1053/j.gastro.2003.10.047.
8
Antithrombotic activity of TNF-alpha.肿瘤坏死因子-α的抗血栓形成活性。
J Clin Invest. 2003 Nov;112(10):1589-96. doi: 10.1172/JCI19284.
9
Randomized, double-blind, placebo-controlled, pilot trial of infliximab, a chimeric monoclonal antibody to tumor necrosis factor-alpha, in patients with moderate-to-severe heart failure: results of the anti-TNF Therapy Against Congestive Heart Failure (ATTACH) trial.肿瘤坏死因子-α嵌合单克隆抗体英夫利昔单抗治疗中重度心力衰竭的随机、双盲、安慰剂对照试验：抗TNF治疗充血性心力衰竭（ATTACH）试验结果
Circulation. 2003 Jul 1;107(25):3133-40. doi: 10.1161/01.CIR.0000077913.60364.D2. Epub 2003 Jun 9.
10
Retinal vein thrombosis after infliximab (Remicade) treatment for Crohn's disease.英夫利昔单抗（类克）治疗克罗恩病后发生视网膜静脉血栓形成
Am J Gastroenterol. 2003 Apr;98(4):939-40. doi: 10.1111/j.1572-0241.2003.07368.x.

一名克罗恩病患者接受英夫利昔单抗治疗后发生急性冠状动脉综合征

Acute coronary syndrome after infliximab therapy in a patient with Crohn's disease.

作者信息

Panteris Vasilios, Perdiou Anna, Tsirimpis Vasilios, Karamanolis Demetrios-Georgios

机构信息

Department of Gastroenterology, "Tzaneio" General Hospital, Piraeus, Greece.

出版信息

World J Gastroenterol. 2006 Oct 14;12(38):6235-8. doi: 10.3748/wjg.v12.i38.6235.

DOI:10.3748/wjg.v12.i38.6235
PMID:17036404
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4088126/
Abstract

Infliximab is a potent anti-TNF antibody, which is used with great success in Crohn's disease patients. Since its release in clinical practice, several adverse reactions have been observed. The interest in possible consequences of its administration is still high because of the recent introduction of the drug for the long-term maintenance therapy of refractory luminal and fistulizing Crohn's disease. We present a case of acute coronary syndrome (non-STEMI) in a patient with corticoid resistant Crohn's disease after his first dose of infliximab. By reviewing the scant articles that exist in the literature on this topic we made an effort to delineate the possible mechanisms of this phenomenon.

摘要

英夫利昔单抗是一种强效抗TNF抗体，在克罗恩病患者中使用取得了巨大成功。自其在临床实践中应用以来，已观察到多种不良反应。由于该药物最近被用于难治性肠腔型和瘘管型克罗恩病的长期维持治疗，人们对其使用可能产生的后果仍高度关注。我们报告一例皮质类固醇抵抗的克罗恩病患者在首次注射英夫利昔单抗后发生急性冠状动脉综合征（非ST段抬高型心肌梗死）的病例。通过查阅文献中关于该主题的少量文章，我们努力阐明了这一现象可能的机制。