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Structure and dynamics of SARS coronavirus main proteinase (Mpro).

作者信息

Hilgenfeld Rolf, Anand Kanchan, Mesters Jeroen R, Rao Zihe, Shen Xu, Jiang Hualiang, Tan Jinzhi, Verschueren Koen H G

机构信息

University of Lübeck, Germany.

出版信息

Adv Exp Med Biol. 2006;581:585-91. doi: 10.1007/978-0-387-33012-9_106.

DOI:10.1007/978-0-387-33012-9_106
PMID:17037602
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7123470/
Abstract
摘要

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本文引用的文献

1
pH-dependent conformational flexibility of the SARS-CoV main proteinase (M(pro)) dimer: molecular dynamics simulations and multiple X-ray structure analyses.严重急性呼吸综合征冠状病毒主要蛋白酶(M(pro))二聚体的pH依赖性构象灵活性:分子动力学模拟和多重X射线结构分析
J Mol Biol. 2005 Nov 18;354(1):25-40. doi: 10.1016/j.jmb.2005.09.012. Epub 2005 Sep 23.
2
Design of wide-spectrum inhibitors targeting coronavirus main proteases.针对冠状病毒主要蛋白酶的广谱抑制剂设计。
PLoS Biol. 2005 Oct;3(10):e324. doi: 10.1371/journal.pbio.0030324. Epub 2005 Sep 6.
3
Critical assessment of important regions in the subunit association and catalytic action of the severe acute respiratory syndrome coronavirus main protease.对严重急性呼吸综合征冠状病毒主要蛋白酶亚基缔合及催化作用中重要区域的批判性评估。
J Biol Chem. 2005 Jun 17;280(24):22741-8. doi: 10.1074/jbc.M502556200. Epub 2005 Apr 14.
4
Mechanism of the maturation process of SARS-CoV 3CL protease.严重急性呼吸综合征冠状病毒3C样蛋白酶成熟过程的机制
J Biol Chem. 2005 Sep 2;280(35):31257-66. doi: 10.1074/jbc.M502577200. Epub 2005 Mar 23.
5
Molecular mechanisms of severe acute respiratory syndrome (SARS).严重急性呼吸综合征(SARS)的分子机制
Respir Res. 2005 Jan 20;6(1):8. doi: 10.1186/1465-9921-6-8.
6
Quaternary structure of the severe acute respiratory syndrome (SARS) coronavirus main protease.严重急性呼吸综合征(SARS)冠状病毒主要蛋白酶的四级结构。
Biochemistry. 2004 Nov 30;43(47):14958-70. doi: 10.1021/bi0490237.
7
Severe acute respiratory syndrome coronavirus 3C-like proteinase N terminus is indispensable for proteolytic activity but not for enzyme dimerization. Biochemical and thermodynamic investigation in conjunction with molecular dynamics simulations.严重急性呼吸综合征冠状病毒3C样蛋白酶N端对于蛋白水解活性必不可少,但对于酶的二聚化并非如此。结合分子动力学模拟的生化和热力学研究。
J Biol Chem. 2005 Jan 7;280(1):164-73. doi: 10.1074/jbc.M408211200. Epub 2004 Oct 26.
8
Dissection study on the severe acute respiratory syndrome 3C-like protease reveals the critical role of the extra domain in dimerization of the enzyme: defining the extra domain as a new target for design of highly specific protease inhibitors.严重急性呼吸综合征3C样蛋白酶的剖析研究揭示了额外结构域在该酶二聚化中的关键作用:将额外结构域定义为设计高特异性蛋白酶抑制剂的新靶点。
J Biol Chem. 2004 Jun 4;279(23):24765-73. doi: 10.1074/jbc.M311744200. Epub 2004 Mar 22.
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The crystal structures of severe acute respiratory syndrome virus main protease and its complex with an inhibitor.严重急性呼吸综合征病毒主要蛋白酶及其与一种抑制剂复合物的晶体结构。
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Biosynthesis, purification, and substrate specificity of severe acute respiratory syndrome coronavirus 3C-like proteinase.严重急性呼吸综合征冠状病毒3C样蛋白酶的生物合成、纯化及底物特异性
J Biol Chem. 2004 Jan 16;279(3):1637-42. doi: 10.1074/jbc.M310875200. Epub 2003 Oct 15.