Al-Kubaisy W A, Al-Naib K T, Habib M A
Department of Community Medicine, Al-Nahrain University, Baghdad, Iraq.
East Mediterr Health J. 2006 May-Jul;12(3-4):264-9.
To estimate the seroprevalence of HCV infection among HIV-infected haemophiliacs and to demonstrate the most prevalent HCV genotype, 47 HIV-infected haemophilia patients were screened for anti-HCV antibodies. By performing polymerase chain reaction and DNA enzyme immunoassay, HCV-RNA was detected with subsequent genotyping. Seroprevalence of anti-HCV antibodies was 66.0%. Of 31 HCV/HIV co-infected patients, 21 (67.7%) had no history of blood transfusion. We detected 4 HCV genotypes: 1a, 1b, 4 and 4 mixed with 3a, HCV-1b being the most frequent. Contaminated factor VIII (clotting factor) could be responsible for disease acquisition.
为评估感染人类免疫缺陷病毒（HIV）的血友病患者中丙型肝炎病毒（HCV）感染的血清流行率，并确定最常见的HCV基因型，对47例感染HIV的血友病患者进行了抗HCV抗体筛查。通过聚合酶链反应和DNA酶免疫测定法检测HCV-RNA并进行基因分型。抗HCV抗体的血清流行率为66.0%。在31例HCV/HIV合并感染患者中，21例（67.7%）无输血史。我们检测到4种HCV基因型：1a、1b、4型以及4型与3a型的混合基因型，其中HCV-1b型最为常见。污染的凝血因子VIII（凝血因子）可能是导致感染的原因。
