Walker W H, Netz M, Gänshirt K H
Biotrans GmbH, Dreieich.
Beitr Infusionsther. 1990;26:55-9.
The red cell preservation solution PAGGS-Mannitol differs from the well documented PAGGS-Sorbitol only by the exchange from Sorbitol in Mannitol. In a clinical investigation with volunteers, up to 21 of the pure PAGGS-Mannitol solution were infused within 4 h. Blood and urine parameters were determined. The solution was well tolerated, no unexpected change of blood and urine parameters was found. The 24 h red cell in vivo survival rate of PAGGS-Mannitol was found to be 74.5 +/- 4.4%, after 49 days storage, a value which was described for PAGGS-Sorbitol before. In vitro data on storage of red cell concentrates with and without buffy coat were determined for hemolysis, 2,3-DPG and ATP using a blood bag system with DEHP and TOTM plastisized PVC. If 1% hemolysis is regarded as acceptable, red cell concentrates can be stored in PAGGS-Mannitol with a TOTM plastisized blood bag system up to 42 days. Under these conditions the amount of plastisizer in the red cell concentrate was found to be only 1% of the amount determined in a standard DEHP plastisized PVC blood bag system.
红细胞保存液PAGGS - 甘露醇与已被充分记录的PAGGS - 山梨醇的区别仅在于将山梨醇换成了甘露醇。在一项针对志愿者的临床研究中，在4小时内输注了多达21单位的纯PAGGS - 甘露醇溶液。测定了血液和尿液参数。该溶液耐受性良好，未发现血液和尿液参数有意外变化。发现PAGGS - 甘露醇在储存49天后的24小时红细胞体内存活率为74.5±4.4%，这是之前报道的PAGGS - 山梨醇的值。使用含有DEHP和TOTM增塑PVC的血袋系统，测定了有无白膜的红细胞浓缩液在储存时的体外溶血、2,3 - 二磷酸甘油酸（2,3 - DPG）和三磷酸腺苷（ATP）数据。如果将1%的溶血率视为可接受，红细胞浓缩液可在含有TOTM增塑血袋系统的PAGGS - 甘露醇中储存长达42天。在这些条件下，发现红细胞浓缩液中的增塑剂含量仅为标准DEHP增塑PVC血袋系统中测定量的1%。
