Storch Eric A, Bagner Daniel M, Geffken Gary R, Adkins Jennifer W, Murphy Tanya K, Goodman Wayne K
Department of Psychiatry, University of Florida, Gainesville, Florida 326110, USA.
Depress Anxiety. 2007;24(6):375-81. doi: 10.1002/da.20260.
Few data have been reported on the efficacy of cognitive-behavioral therapy (CBT) for youth with obsessive-compulsive disorder (OCD) who have not responded to prior treatment with medication. Given this, we report an open trial of CBT for children who have remained symptomatic following medication trials. Five children with OCD who had an inadequate response to psychotropic medications (e.g., limited response and/or unable to be titrated to a complete dose due to side effects) received treatment in a 3-week intensive CBT program. Assessments were conducted at baseline and after treatment. All participants were classified as treatment responders (much improved or very much improved) and the severity of clinician-rated OCD symptoms and impairment significantly decreased after the intervention. Although a number of limitations of this preliminary report exist, this study provides preliminary support for the utility of an intensive intervention for youth with OCD who have had an inadequate response and/or adverse side effects.
关于认知行为疗法（CBT）对之前药物治疗无效的患有强迫症（OCD）的青少年的疗效，鲜有数据报道。鉴于此，我们报告了一项针对药物试验后仍有症状的儿童的CBT开放试验。五名对精神药物反应不佳（例如反应有限和/或因副作用无法滴定至全剂量）的强迫症儿童参加了为期3周的强化CBT项目治疗。在基线和治疗后进行评估。所有参与者均被归类为治疗有反应者（有很大改善或非常有改善），干预后临床医生评定的强迫症症状严重程度和损害显著降低。尽管本初步报告存在一些局限性，但本研究为对反应不佳和/或有不良副作用的患有强迫症的青少年进行强化干预的效用提供了初步支持。
