CCC Tübingen, Department of Radiation Oncology, Hoppe-Seyler-Str. 3, 72076 Tübingen, Germany.
Radiat Oncol. 2006 Oct 17;1:39. doi: 10.1186/1748-717X-1-39.
New concepts in radiation oncology are based on the concept that combinations of irradiation and molecular targeted drugs can yield synergistic or at least additive effects. Up to now the combination of two treatment modalities has been tested in almost all cases. Similar to conventional anti-cancer agents, the efficacy of targeted approaches is also subject to predefined resistance mechanisms. Therefore, it seems reasonable to speculate that a combination of more than two agents will ultimately increase the therapeutic gain. No tools for a bio-mathematical evaluation of a given degree of interaction for more than two anti-neoplastic agents are currently available. The present work introduces a new method for an evaluation of triple therapies and provides some graphical examples in order to visualize the results.
放射肿瘤学的新概念基于这样一种理念，即放疗与分子靶向药物的联合应用可以产生协同或至少相加的效果。到目前为止，几乎所有情况下都已经测试了两种治疗方式的联合应用。与传统抗癌药物类似，靶向方法的疗效也受到预先确定的耐药机制的影响。因此，推测联合应用两种以上药物最终将增加治疗效果似乎是合理的。目前尚无用于评估两种以上抗肿瘤药物相互作用程度的生物数学工具。本研究介绍了一种评估三联疗法的新方法，并提供了一些图形示例，以便可视化结果。
