两名接受环丙沙星治疗的囊性纤维化患者出现凝血障碍。

Coagulopathy in two patients with cystic fibrosis treated with ciprofloxacin.

作者信息

Moore Gillian C, Redfern Jan, Shiach Caroline R, Webb Kevin, Jones Andrew M

机构信息

Manchester Adult Cystic Fibrosis Unit, North West Lung Centre, Wythenshawe Hospital, Southmoor Road, Wythenshawe, Manchester, M23 9LT, UK.

出版信息

J Cyst Fibros. 2007 May;6(3):209-11. doi: 10.1016/j.jcf.2006.08.002. Epub 2006 Oct 12.

DOI:10.1016/j.jcf.2006.08.002

PMID:17045852

Abstract

We report two cases of prolonged blood clotting times as demonstrated by a raised international normalised ratio and elevated activated partial thromboplastin time in patients with cystic fibrosis taking ciprofloxacin. The potential mechanisms of a coagulopathy of this picture as an adverse drug reaction with ciprofloxacin are discussed along with the possible clinical consequences for patients with cystic fibrosis.

摘要

我们报告了两例囊性纤维化患者服用环丙沙星后出现凝血时间延长的病例，表现为国际标准化比值升高和活化部分凝血活酶时间延长。本文讨论了这种情况作为环丙沙星药物不良反应导致凝血病的潜在机制，以及对囊性纤维化患者可能产生的临床后果。