Musk Michael, Chambers Daniel, Chin Weng, Murray Ronan, Gabbay Eli
Lung Transplant Unit, Royal Perth Hospital, Perth, Western Australia, Australia.
J Heart Lung Transplant. 2006 Oct;25(10):1268-72. doi: 10.1016/j.healun.2006.06.002.
Scedosporium species (sp) can cause disseminated disease in lung transplant recipients with almost universal mortality. We present 2 cases of disseminated disease, which responded to voriconazole therapy. In the first case, polymerase chain reaction was used to make a rapid diagnosis and allow differentiation from Aspergillus sp. In this patient, Scedosporium sp could be isolated in the urine despite therapy, and direct irrigation of the renal tract with voriconazole was used with apparent efficacy. In the other case, withdrawal of therapy resulted in clinical relapse, suggesting that lifelong therapy is probably required.
赛多孢子菌可在肺移植受者中引起播散性疾病，几乎普遍导致死亡。我们报告2例播散性疾病病例，其对伏立康唑治疗有反应。在第一例中，使用聚合酶链反应进行快速诊断，并与曲霉菌进行鉴别。在该患者中，尽管接受了治疗，仍可在尿液中分离出赛多孢子菌，使用伏立康唑直接冲洗尿路，效果明显。在另一例中，停止治疗导致临床复发，提示可能需要终身治疗。
