Hübner Claudia
Institut für Geschichte der Medizin, Naturwissenschaft und Technik, Ernst-Haeckel-Haus, Friedrich-Schiller-Universität Jena, Berggasse 7, D-07745 Jena, Germany.
Theory Biosci. 2006 Mar;124(3-4):371-96. doi: 10.1016/j.thbio.2005.11.004. Epub 2006 Jan 27.
This article focuses on the interphyletic comparison of gene expression patterns. By means of the hypothesis of the inversion of the dorsoventral axis during the evolution of the Bilateria, it is demonstrated, that evolutionary developmental biologists use similarities in spatial and temporal gene expression patterns as evidence for the formulation of hypotheses of homology concerning either developing structures or body regions. The molecular genetic and morphogenetic evidence used is discussed within the framework of a cladistic-phylogenetic analysis based on the phylogenetic tree of the Bilateria. I argue that similarity of spatial and temporal gene expression patterns is not a sufficient criterion for homology inference. Therefore, gene expression patterns should be coded as characters. Their homology should be tested in concert with other characters. Furthermore, it is demonstrated, that spatial and temporal similar gene expression patterns, indicating similar molecular genetic mechanisms, were interpreted as an analytical criterion of homology, offering the possibility to identify similar structures. In contrast to this, the evolutionary developmental biologists have not developed a causal-analytically extended concept of shape, from which a causal-analytical concept of homology could be deduced. Instead, the homology concept from evolutionary morphology is used.
本文聚焦于种间基因表达模式的比较。借助两侧对称动物进化过程中背腹轴反转的假说，证明了进化发育生物学家将时空基因表达模式的相似性作为证据，用以构建关于发育结构或身体区域同源性假说。所使用的分子遗传学和形态发生学证据在基于两侧对称动物系统发育树的分支系统发育分析框架内进行了讨论。我认为时空基因表达模式的相似性并非同源性推断的充分标准。因此，基因表达模式应编码为性状。其同源性应与其他性状协同检验。此外，研究表明，时空相似的基因表达模式，表明相似的分子遗传机制，被解释为同源性的分析标准，为识别相似结构提供了可能。与此相反，进化发育生物学家尚未发展出一个因果分析扩展的形状概念，从中可以推导出同源性的因果分析概念。相反，使用的是进化形态学中的同源性概念。
