Heydorn K
Isotope Division, Risł National Laboratory, Roskilde, Denmark.
Biol Trace Elem Res. 1990 Jul-Dec;26-27:541-51. doi: 10.1007/BF02992710.
Chemometric techniques may be applied to extract significant analytical information from a series of publications that present methods and results for determining trace elements in biological material. This approach was applied to the total of 28 papers published in 1971-1988 that reported determination of vanadium in normal human serum or plasma; the levels spanned four orders of magnitude. The most important factors affecting the analytical results were found to be the choice of analytical method and the experience of the laboratory in trace-element research. Results from the most experienced laboratories with the best analytical methods were found to be correlated with the precision of the data, indicating that the correct concentration of vanadium would be less than 1 mg/m3. This is in agreement with results subsequently obtained by radiochemical neutron activation analysis of eight samples of serum from Danish colleagues.
化学计量学技术可用于从一系列介绍生物材料中微量元素测定方法和结果的出版物中提取重要的分析信息。该方法应用于1971年至1988年发表的总共28篇报告正常人血清或血浆中钒测定的论文；其含量范围跨越四个数量级。发现影响分析结果的最重要因素是分析方法的选择以及实验室在微量元素研究方面的经验。发现最有经验的实验室采用最佳分析方法所得到的结果与数据的精确度相关，这表明钒的正确浓度应小于1毫克/立方米。这与丹麦同事随后对八个血清样本进行放射化学中子活化分析所得到的结果一致。
