杂合酶的定向进化：锚定在蛋白质上的非手性铑配合物对映选择性的进化
Directed evolution of hybrid enzymes: Evolving enantioselectivity of an achiral Rh-complex anchored to a protein.
作者信息
Reetz Manfred T, Peyralans Jérôme J-P, Maichele Andrea, Fu Yu, Maywald Matthias
机构信息
Max-Planck-Institut für Kohlenforschung, D-45470 Mülheim/Ruhr, Germany.
出版信息
Chem Commun (Camb). 2006 Nov 4(41):4318-20. doi: 10.1039/b610461d. Epub 2006 Sep 5.
DOI:10.1039/b610461d
PMID:17047853
Abstract
The concept of utilizing the methods of directed evolution for tuning the enantioselectivity of synthetic achiral metal-ligand centers anchored to proteins has been implemented experimentally for the first time.
摘要
利用定向进化方法来调节锚定在蛋白质上的合成非手性金属-配体中心的对映选择性这一概念，首次通过实验得以实现。
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