Shannan B, Seifert M, Boothman D A, Tilgen W, Reichrath J
Department of Dermatology, The Saarland University Hospital, Building 18, Homburg/Saar 66421, Germany.
J Mol Histol. 2006 Sep;37(5-7):183-8. doi: 10.1007/s10735-006-9052-7. Epub 2006 Sep 19.
The glycoprotein clusterin (CLU), has two known isoforms generated in human cells. A nuclear form of CLU protein (nCLU) is pro-apoptotic, while a secretory form (sCLU) is pro-survival. Both forms are implicated in various cell functions, including DNA repair, cell cycle regulation, and apoptotic cell death. CLU expression has been associated with tumorigenesis and the progression of various malignancies. In response to DNA damage, cell survival can be enhanced by activation of DNA repair mechanisms, while simultaneously stimulating energy-expensive cell cycle checkpoints that delay the cell cycle progression to allow more time for DNA repair. This review summarizes our current understanding of the role of clusterin in DNA repair, apoptosis, and cell cycle control and the relevance.
糖蛋白聚集素（CLU）在人类细胞中有两种已知的异构体。CLU蛋白的核形式（nCLU）具有促凋亡作用，而分泌形式（sCLU）具有促生存作用。这两种形式都参与多种细胞功能，包括DNA修复、细胞周期调控和凋亡性细胞死亡。CLU的表达与肿瘤发生及各种恶性肿瘤的进展相关。在DNA损伤时，激活DNA修复机制可增强细胞存活能力，同时刺激耗能的细胞周期检查点，这些检查点会延迟细胞周期进程，以便为DNA修复留出更多时间。本综述总结了我们目前对聚集素在DNA修复、凋亡和细胞周期控制中的作用及其相关性的理解。
