[不同粒径复方中药麻杏石甘汤超微颗粒中麻黄碱与d-伪麻黄碱的溶解度]
[Solubilities of ephedrine and d-pseudo-ephedrine from different sizes of ultramicro-particles of the compound traditional Chinese herbs Maxing Shigan decoction].
作者信息
Si Nan, Yang Jian, Bian Bao-lin
机构信息
Institute of Chinese Material Medica, China Academy of Chinese Medicial Sciences, Beijing 100700, China.
出版信息
Zhongguo Zhong Yao Za Zhi. 2006 Jun;31(11):884-6.
OBJECTIVE
To compare the solubilities of ephedrine and d-pseudo-ephdrine in the compound of traditional Chinese drugs--Maxing Shigan decoction with and without ultramicro-pulverizations using a RP-HPLC procedure.
METHOD
The analytical column was a YMC ODS-C18(4.6 mm x 150 mm,4 microm). A mixture of water-acetonitrile-sodium dodecyl sulfate-phosphorous acid (650:350:5:1) was used as the mobile phase at flow rate of 1.5 mL x min(-1). The column temperature was 50 degrees C and the wavelength was 210 nm.
RESULT
In this way, ephedrine and d-pseudo-ephedrine of the compound samples can be separated well and showed significant differences before and after the ultramicro-pulverizations.
CONCLUSION
For the Maxing Shigan decoction, the dissolution rates and solubilites of ephedrine and d-pseudo-ephedrine ultramicro-pulverization were greatly improved.
目的
采用反相高效液相色谱法（RP-HPLC）比较麻黄碱和d-伪麻黄碱在中药复方——麻杏石甘汤及其超微粉碎制剂中的溶解度。
方法
分析柱为YMC ODS-C18（4.6 mm×150 mm，4μm）。以水-乙腈-十二烷基硫酸钠-磷酸（650:350:5:1）混合液为流动相，流速为1.5 mL·min⁻¹。柱温为50℃，检测波长为210 nm。
结果
采用该方法，复方样品中的麻黄碱和d-伪麻黄碱能够得到良好分离，且超微粉碎前后有显著差异。
结论
对于麻杏石甘汤，超微粉碎后麻黄碱和d-伪麻黄碱的溶出速率和溶解度有显著提高。
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