Fan Dong-Li, Liao Qing-Wen, Yan Dan, Ma Xiao-Jun, Xiao Xiao-He, Zhao Yan-Ling
Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100094, China.
Zhongguo Zhong Yao Za Zhi. 2007 Mar;32(5):421-4.
To probe into the objectivity and authenticity of four properties beteen Mahuang decoction and Maxing Shigan decoction from biothermodynamics.
The power-time curves of growth of Staphylococcus aureus at different concentrations between Mahuang decoction and Maxing Shigan decoction were determined by TAM Air Isothermal Calorimeter. The growth rate constants of promotive and inhibitory actions were calculated. Moreover, the difference of properties beteen Mahuang decoction and Maxing Shigan decoction was analyzed from the point of view of TCM theory.
Both the Mahuang decoction and Maxing Shigan decoction could inhibit the growth and metabolism of Staphylococcus aureus. The k and Pm were decreased with the mass increase of the decoction. However, inhibitory activity of Mahuang decoction with warm property was weaker than that of Maxing Shigan decoction with cool property. Moreover, Mahuang decoction decreased heat output in growth metabolism more weakly than Maxing Shigan decoction. There was a stable difference between them.
Studying on biothermodynamics can show the difference of four properties of Traditional Chinese Medicine. So, it provides a new and useful means for the study of the properties of traditional Chinese medicine.
从生物热动力学角度探讨麻黄汤与麻杏石甘汤四性的客观性与真实性。
采用TAM Air等温微量热仪测定麻黄汤和麻杏石甘汤不同浓度下金黄色葡萄球菌生长的功率-时间曲线，计算促进和抑制作用的生长速率常数，并从中医理论角度分析麻黄汤与麻杏石甘汤的药性差异。
麻黄汤和麻杏石甘汤均能抑制金黄色葡萄球菌的生长代谢，随着汤剂质量增加，k和Pm降低。但温热性的麻黄汤抑制活性弱于寒凉性的麻杏石甘汤，且麻黄汤在生长代谢中降低热输出的作用也弱于麻杏石甘汤，二者存在稳定差异。
生物热动力学研究能体现中药四性差异，为中药药性研究提供了一种新的有用方法。
