McHeyzer-Williams L J, Malherbe L P, McHeyzer-Williams M G
The Scripps Research Institute, 10550 North Torrey Pines Road, ICND 120, La Jolla, CA 92037, USA.
Curr Top Microbiol Immunol. 2006;311:59-83. doi: 10.1007/3-540-32636-7_3.
In this review, we will discuss the cascade of cellular and molecular events in the immune response to protein antigens that regulate the development of high-affinity B cell memory. The behavior of antigen-experienced pMHCII+ dendritic cells DCs and the dynamics of their interaction with specific T-helper (Th) cells define the first developmental checkpoint for adaptive immunity in vivo. Recent studies provide insight into the basis of Th cell clonal selection and the requirements and consequences of antigen priming in this responsive Th cell compartment. Antigen-specific Th cells expand to become the cognate regulators of effector B cell responses and initiators of the germinal center reaction and memory B cell development. We will discuss the development and role of these diverse mixtures of antigen-specific B cells in the control of B cell memory and long-term humoral immunity that underpin effective protein vaccination.
在本综述中，我们将讨论针对蛋白质抗原的免疫应答中细胞和分子事件的级联反应，这些反应调节高亲和力B细胞记忆的形成。抗原经历过的pMHCII⁺树突状细胞（DCs）的行为及其与特异性辅助性T（Th）细胞相互作用的动力学定义了体内适应性免疫的第一个发育检查点。最近的研究深入了解了Th细胞克隆选择的基础以及在这个反应性Th细胞区室中抗原启动的要求和后果。抗原特异性Th细胞扩增成为效应B细胞反应的同源调节因子以及生发中心反应和记忆B细胞发育的启动者。我们将讨论这些不同的抗原特异性B细胞混合物在控制B细胞记忆和长期体液免疫中的发育和作用，而B细胞记忆和长期体液免疫是有效蛋白质疫苗接种的基础。
