Tan J T, Surh C D
Department of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Rd., La Jolla, CA 92037, USA.
Curr Top Microbiol Immunol. 2006;311:85-115. doi: 10.1007/3-540-32636-7_4.
T cell memory induced by prior infection or vaccination provides enhanced protection against subsequent microbial infections. The processes involved in generating and maintaining T cell memory are becoming better understood due to recent technological advances in identifying memory T cells and monitoring their behavior and function in vivo. Memory T cells develop in response to a progressive set of cues-starting with signals from antigen-loaded, activated antigen-presenting cells (APCs) and inflammatory mediators induced by the innate immune response, to the poorly defined subsequent signals triggered as the immune response wanes toward homeostasis. The persistence of the resting memory T cells that eventually develop is regulated by cytokines. This chapter discusses recent findings on how memory T cells develop to confer long-term protective immunity.
先前感染或疫苗接种诱导产生的T细胞记忆可增强对后续微生物感染的保护作用。由于在识别记忆T细胞以及监测其在体内的行为和功能方面的最新技术进展，生成和维持T细胞记忆所涉及的过程正逐渐被人们更好地理解。记忆T细胞是在一系列渐进性线索的作用下发育形成的，起始于来自负载抗原的活化抗原呈递细胞（APC）的信号以及先天免疫反应诱导产生的炎性介质，随后是随着免疫反应趋向稳态减弱而触发的定义不清的后续信号。最终形成的静止记忆T细胞的持久性受细胞因子调控。本章讨论了关于记忆T细胞如何发育以赋予长期保护性免疫的最新研究发现。
