Zhu Jianglong, Porco John A
Department of Chemistry and Center for Chemical Methodology and Library Development, Boston University, Boston, MA 02215, USA
Org Lett. 2006 Oct 26;8(22):5169-71. doi: 10.1021/ol062233m.
Asymmetric syntheses of (-)-mitorubrin and related azaphilone natural products are reported. Key steps involve copper-mediated, enantioselective oxidative dearomatization to prepare the azaphilone core and olefin cross-metathesis for side-chain installation. [reaction: see text]
报道了(-)-米托鲁宾及相关氮杂稠酮天然产物的不对称合成。关键步骤包括铜介导的对映选择性氧化脱芳构化以制备氮杂稠酮核心，以及用于侧链安装的烯烃交叉复分解反应。[反应：见正文]
