（-）-米托鲁宾及相关氮杂稠酮天然产物的不对称合成。
Asymmetric syntheses of (-)-mitorubrin and related azaphilone natural products.
作者信息
Zhu Jianglong, Porco John A
机构信息
Department of Chemistry and Center for Chemical Methodology and Library Development, Boston University, Boston, MA 02215, USA
出版信息
Org Lett. 2006 Oct 26;8(22):5169-71. doi: 10.1021/ol062233m.
PMID:17048870
Abstract
Asymmetric syntheses of (-)-mitorubrin and related azaphilone natural products are reported. Key steps involve copper-mediated, enantioselective oxidative dearomatization to prepare the azaphilone core and olefin cross-metathesis for side-chain installation. [reaction: see text]
摘要
报道了(-)-米托鲁宾及相关氮杂稠酮天然产物的不对称合成。关键步骤包括铜介导的对映选择性氧化脱芳构化以制备氮杂稠酮核心，以及用于侧链安装的烯烃交叉复分解反应。[反应：见正文]
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