Kananovich Dzmitry, Elek Gábor Zoltán, Lopp Margus, Borovkov Victor
Department of Chemistry and Biotechnology, School of Science, Tallinn University of Technology, Tallinn, Estonia.
Front Chem. 2021 Mar 30;9:614944. doi: 10.3389/fchem.2021.614944. eCollection 2021.
Despite the remarkable advances in the area of asymmetric catalytic oxidations over the past decades, the development of sustainable and environmentally benign enantioselective oxidation techniques, especially with the efficiency level similar to natural enzymes, still represents a challenge. The growing demand for enantiopure compounds and high interest to industry-relevant green technological advances continue to encourage the research pursuits in this field. Among various oxidants, molecular oxygen is ubiquitous, being available at low cost, environmentally benign and easy-to-handle material. This review highlights recent achievements in catalytic enantioselective oxidations utilizing molecular oxygen as the sole oxidant, with focus on the mechanisms of dioxygen activation and chirogenesis in these transformations.
尽管在过去几十年里不对称催化氧化领域取得了显著进展，但开发可持续且环境友好的对映选择性氧化技术，尤其是效率水平与天然酶相似的技术，仍然是一项挑战。对映纯化合物的需求不断增长，以及对与工业相关的绿色技术进展的高度关注，继续推动着该领域的研究。在各种氧化剂中，分子氧无处不在，是一种低成本、环境友好且易于处理的材料。本文综述了以分子氧为唯一氧化剂的催化对映选择性氧化的最新进展，重点关注这些转化中双氧活化和手性产生的机制。
