利用铜介导的对映选择性氧化脱芳构化反应合成氮杂蒽酮类化合物。
Synthesis of the azaphilones using copper-mediated enantioselective oxidative dearomatization.
作者信息
Zhu Jianglong, Grigoriadis Nicholas P, Lee Jonathan P, Porco John A
机构信息
Department of Chemistry and Center for Chemical Methodology and Library Development, Boston University, Boston, Massachusetts 02215, USA.
出版信息
J Am Chem Soc. 2005 Jul 6;127(26):9342-3. doi: 10.1021/ja052049g.
PMID:15984841
Abstract
An approach to the asymmetric synthesis of the azaphilone natural products is reported involving copper-mediated enantioselective oxidative dearomatization of o-alkynylbenzaldehydes. The approach was successfully applied to the synthesis of (-)-S-15183a and several unnatural azaphilones.
摘要
报道了一种氮杂蒽酮天然产物的不对称合成方法，该方法涉及铜介导的邻炔基苯甲醛的对映选择性氧化去芳构化反应。该方法已成功应用于（-）-S-15183a和几种非天然氮杂蒽酮的合成。
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