Parkinson Gillian M
University of Manchester, Manchester, UK.
Pediatr Rehabil. 2006 Jul-Sep;9(3):229-46. doi: 10.1080/13638490500403080.
The intention of this study was to examine specific pragmatic functions in 35 children, aged 6-11 years, with a history of epilepsy (mean length of duration 6.5 years), who demonstrated autistic features, ASD or autistic regression.
The children's ability to recognize and convey communicative intentions, conversational engagement and paralinguistic features were investigated using the Pragmatics Profile of Everyday Communication Skills in Children using semi-structured key-worker interviews. The association between weak or abnormal prosody and epileptic focus was also examined.
Findings demonstrate a strong association between early onset epilepsy with autism or autistic regression and additional pragmatic impairment. A number of children exhibited weak or abnormal prosody in association with temporal lobe EEG abnormalities, particularly in the non-dominant hemisphere. Consideration is given to recent studies of the converse--the presence of a reducing prevalence of epilepsy in the autism population and acknowledgment of implications for learning within the autistic population.
本研究旨在考察35名6至11岁有癫痫病史（平均病程6.5年）且表现出自闭特征、自闭症谱系障碍（ASD）或自闭症退化的儿童的特定语用功能。
采用儿童日常沟通技能语用概况，通过半结构化的关键工作人员访谈，调查儿童识别和传达交际意图、对话参与度和副语言特征的能力。同时还研究了弱韵律或异常韵律与癫痫病灶之间的关联。
研究结果表明，早发性癫痫与自闭症或自闭症退化以及额外的语用障碍之间存在密切关联。许多儿童表现出与颞叶脑电图异常相关的弱韵律或异常韵律，尤其是在非优势半球。本文还考虑了近期关于相反情况的研究——自闭症人群中癫痫患病率的降低以及对自闭症人群学习影响的认识。
