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肝脏恶性血管肿瘤中的内皮标志物：QB-END/10相对于血管性血友病因子和荆豆凝集素1的优势

Endothelial markers in malignant vascular tumours of the liver: superiority of QB-END/10 over von Willebrand factor and Ulex europaeus agglutinin 1.

作者信息

Anthony P P, Ramani P

机构信息

Area Department of Pathology, Royal Devon Hospital, Postgraduate Medical School, University of Exeter, Heavitree.

出版信息

J Clin Pathol. 1991 Jan;44(1):29-32. doi: 10.1136/jcp.44.1.29.

DOI:10.1136/jcp.44.1.29
PMID:1705261
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC497010/
Abstract

A new monoclonal antibody, QB-END/10, raised against the CD34 antigen in human endothelial cell membranes and haemopoietic progenitor cells, was studied for its usefulness as a marker of neoplastic vascular cells in 21 angiosarcomas and seven malignant haemangioendotheliomas of the liver. QB-END/10 was both more sensitive and more specific than Von Willebrand factor (VWF) and Ulex europaeus 1 agglutinin (UEA-1) in labelling endothelial cells and it did not cross react with epithelia as UEA-1 often does. Staining was uniformly strong and clear in all histological variants of these two tumours. QB-END/10 should prove particularly useful in the differential diagnosis of malignant vascular tumours of the liver.

摘要

一种新的单克隆抗体QB-END/10，是针对人内皮细胞膜和造血祖细胞中的CD34抗原产生的，我们研究了它作为肿瘤血管细胞标志物在21例血管肉瘤和7例肝脏恶性血管内皮瘤中的应用价值。在标记内皮细胞方面，QB-END/10比血管性血友病因子（VWF）和欧洲荆豆凝集素1（UEA-1）更敏感、更具特异性，并且它不像UEA-1那样经常与上皮细胞发生交叉反应。在这两种肿瘤的所有组织学变体中，染色均均匀强烈且清晰。QB-END/10在肝脏恶性血管肿瘤的鉴别诊断中应会特别有用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe67/497010/9c3ea0cbaeed/jclinpath00403-0039-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe67/497010/49619f382068/jclinpath00403-0038-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe67/497010/7bc48e0e9fbc/jclinpath00403-0038-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe67/497010/d997c606d10d/jclinpath00403-0039-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe67/497010/9c3ea0cbaeed/jclinpath00403-0039-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe67/497010/49619f382068/jclinpath00403-0038-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe67/497010/7bc48e0e9fbc/jclinpath00403-0038-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe67/497010/d997c606d10d/jclinpath00403-0039-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe67/497010/9c3ea0cbaeed/jclinpath00403-0039-b.jpg

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本文引用的文献

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Evidence for a weak angiogenic response to human colorectal cancers.对人类结直肠癌血管生成反应微弱的证据。
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运用免疫过氧化物酶法对血管内皮细胞中VIII因子相关抗原进行定位。
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Ulex europaeus I lectin as a marker for tumors derived from endothelial cells.荆豆凝集素I作为内皮细胞来源肿瘤的标志物。
Am J Clin Pathol. 1983 Jan;79(1):32-6. doi: 10.1093/ajcp/79.1.32.
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