Torrado J, Blasco E, Cosme A, Gutierrez-Hoyos A, Arenas J I
Pathology Unit, Hospital Nuestra Senora de Aranzazu, San Sebastian, Spain.
Am J Clin Pathol. 1989 Mar;91(3):249-54. doi: 10.1093/ajcp/91.3.249.
The distribution of the blood group-related antigens type 1 (Lewis(a) [Le(a)], Lewis(b) [Le(b)]) and type 2 (H type 2, Y) has been examined in histologically normal and malignant mucosa of 40 surgical specimens of patients with adenocarcinoma of the stomach, with the use of a panel of monoclonal antibodies. Patients' Lewis phenotype and secretor status are correlated to the authors' findings. The surface epithelium of normal pyloric and fundic mucosa expressed the Lewis isoantigen (Le(a) in Le[a+b-] phenotype and Le(b) in Le[a-b+] phenotype), whereas the deep areas of this mucosa no showed the Le(a), Le(b) antigens and expressed the Y and H type 2 antigens whatever the secretor status of patients. Nineteen of 24 patients with Le(a-b+) phenotype showed anomalous expression of Lea antigen in neoplastic cells. In three of them, this alteration was found in tumor adjacent mucosa. No expression of Le(a) or Le(b) antigens was found in tumors or normal mucosa from Le(a-b-) phenotype patients.
利用一组单克隆抗体，对40例胃癌患者手术标本的组织学正常和恶性黏膜中血型相关抗原1型（Lewis(a) [Le(a)]、Lewis(b) [Le(b)]）和2型（H2型、Y）的分布进行了检测。将患者的Lewis表型和分泌状态与作者的研究结果进行了关联分析。正常幽门和胃底黏膜的表面上皮表达Lewis同种抗原（Le[a+b-]表型中为Le(a)，Le[a-b+]表型中为Le(b)），而该黏膜深层无论患者的分泌状态如何，均未显示Le(a)、Le(b)抗原，而是表达Y和H2型抗原。24例Le(a-b+)表型患者中有19例在肿瘤细胞中出现Lea抗原异常表达。其中3例在肿瘤邻近黏膜中发现了这种改变。Le(a-b-)表型患者的肿瘤或正常黏膜中未发现Le(a)或Le(b)抗原表达。
