Woodbury J W, Woodbury D M
Department of Physiology, School of Medicine, University of Utah, Salt Lake City.
Pacing Clin Electrophysiol. 1991 Jan;14(1):94-107. doi: 10.1111/j.1540-8159.1991.tb04053.x.
J. Zabara showed that repetitive vagal stimulation (VS) prevents or ameliorates convulsive seizures in dogs. We have studied the effects of VS on maximal electroshock seizures (MES) in intact rats: (1) A 5 wire cuff electrode was developed for stimulating and recording from the vagus. Compound action potentials (AP) were recorded and strength-duration curves obtained for A and C fibers. There is a monotonic relationship with a negative slope between heart rate (HR) and AP amplitude. C fibers remain excitable for 25 days after cuff implant. (2) The anticonvulsant efficacy of VS is directly related to the fraction of vagal C fibers stimulated and the frequency of stimulation. (3) The anticonvulsant efficacy of VS has been established using two rat models of human epilepsy. VS abolishes the extensor component of the tonic phase of a MES and shortens or prevents tonic seizures induced by pentylenetetrazol (PTZ). (4) VS appears to act via release of large quantities of the inhibitory mediators GABA and glycine throughout large volumes of the brain. (5) It is rational to test VS in man as a treatment for intractable seizures.
J. 扎巴拉指出，重复性迷走神经刺激（VS）可预防或改善犬类的惊厥性癫痫发作。我们研究了VS对完整大鼠最大电休克癫痫发作（MES）的影响：（1）开发了一种五线袖带电极，用于迷走神经的刺激和记录。记录复合动作电位（AP），并获得A和C纤维的强度-时间曲线。心率（HR）与AP振幅之间存在负斜率的单调关系。袖带植入后，C纤维在25天内仍保持可兴奋性。（2）VS的抗惊厥效果与受刺激的迷走神经C纤维比例及刺激频率直接相关。（3）已使用两种人类癫痫大鼠模型确定了VS的抗惊厥效果。VS消除了MES强直期的伸肌成分，并缩短或预防了戊四氮（PTZ）诱导的强直发作。（4）VS似乎通过在大脑的大量区域释放大量抑制性介质γ-氨基丁酸（GABA）和甘氨酸起作用。（5）在人类中测试VS作为治疗难治性癫痫发作的方法是合理的。
