Potential Leydig cell mitogenic signals generated by the wild-type and constitutively active mutants of the lutropin/choriogonadotropin receptor (LHR).
作者信息
Ascoli Mario
机构信息
Department of Pharmacology, 2-319B BSB, 51 Newton Road, The University of Iowa, Iowa City, IA 52242-1109, United States.
出版信息
Mol Cell Endocrinol. 2007 Jan 2;260-262:244-8. doi: 10.1016/j.mce.2005.09.016. Epub 2006 Oct 19.
Abstract
摘要
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1
Potential Leydig cell mitogenic signals generated by the wild-type and constitutively active mutants of the lutropin/choriogonadotropin receptor (LHR).由促黄体生成素/绒毛膜促性腺激素受体（LHR）的野生型和组成型活性突变体产生的潜在睾丸间质细胞有丝分裂信号。
Mol Cell Endocrinol. 2007 Jan 2;260-262:244-8. doi: 10.1016/j.mce.2005.09.016. Epub 2006 Oct 19.
2
A co-culture system reveals the involvement of intercellular pathways as mediators of the lutropin receptor (LHR)-stimulated ERK1/2 phosphorylation in Leydig cells.一种共培养系统揭示了细胞间信号通路作为促黄体生成素受体（LHR）刺激的睾丸间质细胞中ERK1/2磷酸化的介质的作用。
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3
MA-10 cells transfected with the human lutropin/choriogonadotropin receptor (hLHR): a novel experimental paradigm to study the functional properties of the hLHR.用人类促黄体生成素/绒毛膜促性腺激素受体（hLHR）转染的MA-10细胞：一种研究hLHR功能特性的新型实验范式。
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4
The lutropin/choriogonadotropin receptor-induced phosphorylation of the extracellular signal-regulated kinases in leydig cells is mediated by a protein kinase a-dependent activation of ras.促黄体生成素/绒毛膜促性腺激素受体诱导的睾丸间质细胞中细胞外信号调节激酶的磷酸化是由蛋白激酶A依赖性的Ras激活介导的。
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Activation of the lutropin/choriogonadotropin receptor in MA-10 cells stimulates tyrosine kinase cascades that activate ras and the extracellular signal regulated kinases (ERK1/2).促黄体生成素/绒毛膜促性腺激素受体在MA-10细胞中的激活会刺激酪氨酸激酶级联反应，从而激活ras和细胞外信号调节激酶（ERK1/2）。
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Endocytosis of lutropin by Leydig cells through a pathway distinct from the high-affinity receptor.黄体生成素通过一条不同于高亲和力受体的途径被睾丸间质细胞内吞。
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Lutropin/choriogonadotropin stimulate the proliferation of primary cultures of rat Leydig cells through a pathway that involves activation of the extracellularly regulated kinase 1/2 cascade.促黄体生成素/绒促性素通过一条涉及细胞外调节激酶1/2级联激活的途径刺激大鼠睾丸间质细胞原代培养物的增殖。
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Transduction of receptor signals by beta-arrestins.β-抑制蛋白介导的受体信号转导
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2
Ghrelin inhibits the proliferative activity of immature Leydig cells in vivo and regulates stem cell factor messenger ribonucleic acid expression in rat testis.胃饥饿素在体内抑制未成熟睾丸间质细胞的增殖活性，并调节大鼠睾丸中干细胞因子信使核糖核酸的表达。
Endocrinology. 2004 Nov;145(11):4825-34. doi: 10.1210/en.2004-0732. Epub 2004 Jul 29.
3
Extracellular signal-regulated kinases are involved in the acute activation of steroidogenesis in immature rat Leydig cells by human chorionic gonadotropin.细胞外信号调节激酶参与人绒毛膜促性腺激素对未成熟大鼠睾丸间质细胞类固醇生成的急性激活作用。
Endocrinology. 2004 Oct;145(10):4629-34. doi: 10.1210/en.2004-0496. Epub 2004 Jul 8.
4
Development of leydig cells in the insulin-like growth factor-I (igf-I) knockout mouse: effects of igf-I replacement and gonadotropic stimulation.胰岛素样生长因子-I（IGF-I）基因敲除小鼠中睾丸间质细胞的发育：IGF-I替代和促性腺激素刺激的影响
Biol Reprod. 2004 Mar;70(3):632-9. doi: 10.1095/biolreprod.103.022590. Epub 2003 Oct 29.
5
A constitutively active somatic mutation of the human lutropin receptor found in Leydig cell tumors activates the same families of G proteins as germ line mutations associated with Leydig cell hyperplasia.在睾丸间质细胞瘤中发现的人促黄体生成素受体的组成型活性体细胞突变，激活的G蛋白家族与和睾丸间质细胞增生相关的种系突变相同。
Endocrinology. 2003 Sep;144(9):3872-8. doi: 10.1210/en.2003-0365.
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The lutropin/choriogonadotropin receptor-induced phosphorylation of the extracellular signal-regulated kinases in leydig cells is mediated by a protein kinase a-dependent activation of ras.促黄体生成素/绒毛膜促性腺激素受体诱导的睾丸间质细胞中细胞外信号调节激酶的磷酸化是由蛋白激酶A依赖性的Ras激活介导的。
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7
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