Chomette G, Auriol M, Vaillant J M, Kasai T, Okada Y, Mori M
Department of Pathology, Hopital de la Pitié, Paris, France.
J Pathol. 1991 Jan;163(1):39-45. doi: 10.1002/path.1711630108.
Among adenoid cystic carcinomas of salivary glands (ACCs), the solid basaloid type has a poor prognosis similar to that of undifferentiated adenocarcinomas. We studied 24 cases in immunohistochemistry using antibodies reactive with keratins of various molecular weights, vimentin, S-100 protein, and its A and B subunits. Our findings were correlated with the histological pattern and with the variable degree of differentiation of these carcinomas. In comparison with other types of ACC, intermediate filament proteins in this group were weakly expressed. The co-expression of cytokeratin and vimentin was noted in some cases. Additional features noted were the presence of cribriform cavities associated with solid lobules and areas of necrosis giving a comedocarcinomatous pattern. In these two variants, cells characterized by the dual expression of cytokeratin and S-100 protein were seen. In the highly malignant anaplastic variety, only a few cells were weakly positive with antisera to cytokeratin and vimentin. This group shows similarities to undifferentiated adenocarcinomas of salivary glands. Such similarities could be explained by the common origin of these tumours from intercalated ducts.
在涎腺腺样囊性癌（ACC）中，实性基底样型预后较差，与未分化腺癌相似。我们使用与各种分子量角蛋白、波形蛋白、S-100蛋白及其A和B亚基反应的抗体，对24例进行了免疫组织化学研究。我们的发现与这些癌的组织学模式以及不同程度的分化相关。与其他类型的ACC相比，该组中的中间丝蛋白表达较弱。在某些病例中注意到细胞角蛋白和波形蛋白的共表达。其他特征包括与实性小叶相关的筛状腔以及呈现粉刺癌模式的坏死区域。在这两种变体中，可见以细胞角蛋白和S-100蛋白双重表达为特征的细胞。在高度恶性的间变类型中，只有少数细胞对细胞角蛋白和波形蛋白抗血清呈弱阳性。该组与涎腺未分化腺癌相似。这些相似性可以用这些肿瘤起源于闰管来解释。
