Pan L X, Xu J N, Isaacson P G
Department of Histopathology University College and Middlesex School of Medicine, London, U.K.
J Pathol. 1991 Jan;163(1):53-60. doi: 10.1002/path.1711630110.
Cellular H- and M-type lactate dehydrogenase (LDH) isoenzymes were determined immunohistochemically in a wide range of normal, inflammatory, benign neoplastic, and malignant tissues to assess the possible value of the isoenzymes in tumour diagnosis. Both types of LDH were detected almost ubiquitously in normal tissues. Increased staining intensity of LDH, especially M-type LDH, was demonstrated in most types of malignant tumours studied. Similar increased staining intensity of the isoenzymes was also noted to parallel the proliferative activity of the cells in non-neoplastic diseases and benign neoplasms. The results suggest that changes of cellular H- and M-type LDH isoenzymes are not specific for any type of malignant tumours. The increase in cellular H- and M-type LDH isoenzymes appears to be related to proliferation of cells in general.
采用免疫组织化学方法测定了多种正常、炎症、良性肿瘤及恶性组织中的细胞H型和M型乳酸脱氢酶（LDH）同工酶，以评估这些同工酶在肿瘤诊断中的潜在价值。在正常组织中，几乎普遍检测到这两种类型的LDH。在所研究的大多数恶性肿瘤类型中，LDH染色强度增加，尤其是M型LDH。在非肿瘤性疾病和良性肿瘤中，也观察到同工酶染色强度类似的增加，且与细胞的增殖活性平行。结果表明，细胞H型和M型LDH同工酶的变化并非任何类型恶性肿瘤所特有。细胞H型和M型LDH同工酶的增加似乎与细胞的总体增殖有关。
