T-Tomity I, Takács O
Laryngol Rhinol Otol (Stuttg). 1979 Dec;58(12):916-9.
The distribution of lactate dehydrogenase (LDH) isoenzymes in healthy blood donors and in patients suffering histological identified tumor (neoplasms) laryngis was investigated. The values of 110 healthy persons (controls) proved to be comparable with the average data described in literature. The LDH distribution pattern of 90 tumour affected persons showed significant differences comparing with controls. The alteration appears as absolute increase in LDH-1 (H4) isoenzyme parallel with progressive decrease in the hybrid enzyme rations containing M subunits (LDH-2, LDH-3, LDH-4), and the LDH-5 consisting of four M sununits was undetectable. The conclusions drawn from our investigations seem to be in agreement with Warburg's conception, supposing that in malignant tumours the aerob glycolysis increases. The determination of LDH isoenzyme distributions for diagnostic purposes in clinical practice is recommended.
对健康献血者以及经组织学确诊患有喉肿瘤（瘤）患者的乳酸脱氢酶（LDH）同工酶分布情况进行了研究。110名健康人（对照组）的数据与文献中描述的平均数据具有可比性。90名肿瘤患者的LDH分布模式与对照组相比存在显著差异。这种变化表现为LDH-1（H4）同工酶绝对增加，同时含有M亚基的混合酶比例（LDH-2、LDH-3、LDH-4）逐渐降低，且由四个M亚基组成的LDH-5无法检测到。我们的研究得出的结论似乎与瓦尔堡的观点一致，即认为恶性肿瘤中需氧糖酵解增加。建议在临床实践中测定LDH同工酶分布用于诊断目的。
