中风家族史与中风后神经功能缺损的严重程度。
Family history of stroke and severity of neurologic deficit after stroke.
作者信息
Meschia J F, Case L D, Worrall B B, Brown R D, Brott T G, Frankel M, Silliman S, Rich S S
机构信息
Department of Neurology, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA.
出版信息
Neurology. 2006 Oct 24;67(8):1396-402. doi: 10.1212/01.wnl.0000240267.25699.9d.
BACKGROUND
A family history of stroke is an independent risk factor for stroke.
OBJECTIVE
To assess whether severity of neurologic deficit after stroke is associated with a family history of stroke.
METHODS
The Ischemic Stroke Genetics Study, a five-center study of first-ever symptomatic ischemic stroke, assessed case subjects prospectively for a family history of stroke-affected first-degree relatives. Certified adjudicators used the NIH Stroke Scale (NIHSS) to determine the severity of neurologic deficit.
RESULTS
A total of 505 case subjects were enrolled (median age, 65 years; 55% male), with 81% enrolled within 1 week of onset of symptoms. A sibling history of stroke was associated with more severe stroke. The odds of an NIHSS score of 5 or higher were 2.0 times greater for cases with a sibling history of stroke compared with cases with no sibling history (95% CI, 1.0 to 3.9). An association of family history of stroke in parents or children with stroke severity was not detected.
CONCLUSIONS
A sibling history of stroke increased the likelihood of a more severe stroke in the case subjects, independent of age, sex, and other potential confounding factors. Other family history characteristics were not associated with stroke severity.
背景
中风家族史是中风的独立危险因素。
目的
评估中风后神经功能缺损的严重程度是否与中风家族史相关。
方法
缺血性中风遗传学研究是一项针对首次出现症状性缺血性中风的五中心研究，前瞻性地评估病例受试者中风受累一级亲属的家族史。经认证的评判员使用美国国立卫生研究院中风量表（NIHSS）来确定神经功能缺损的严重程度。
结果
共纳入505例病例受试者（中位年龄65岁；55%为男性），81%在症状发作后1周内入组。中风的兄弟姐妹病史与更严重的中风相关。有中风兄弟姐妹病史的病例，NIHSS评分达到5分或更高的几率是无中风兄弟姐妹病史病例的2.0倍（95%CI，1.0至3.9）。未发现父母或子女的中风家族史与中风严重程度之间存在关联。
结论
中风的兄弟姐妹病史增加了病例受试者发生更严重中风的可能性，独立于年龄、性别和其他潜在混杂因素。其他家族史特征与中风严重程度无关。
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