Jürimäe Jaak, Jürimäe Toivo
Institute of Sport Pedagogy and Coaching Sciences, University of Tartu, 18. Ulikooli Street, Tartu 50090, Estonia.
Exp Biol Med (Maywood). 2006 Nov;231(10):1673-7. doi: 10.1177/153537020623101013.
The aim of the present investigation was to study the influence of plasma insulin-like growth factor-1 (IGF-1) and leptin levels on bone mineral mass (BMC) and bone mineral density (BMD) in premenopausal women and the relationship between IGF-1 and leptin levels. Two hundred and four healthy women participated in this study. All participants had a body mass index (BMI) <30 kg/m(2) and were matched for their level of mean daily energy expenditure. BMC and BMD were correlated with measured body composition and blood biochemical parameters. No association was observed between BMC and BMD values with measured physical performance characteristics. Leptin had a significant association with BMC (beta = 0.840; P = 0.0001), total BMD (beta = 0.833; P = 0.0001), femoral neck BMD (beta = 0.829; P = 0.0001), and lumbar spine BMD (beta = 0.833; P = 0.0001). However, these associations were no longer independent when adjusted for body fat mass (FM) and trunk fat:leg fat ratio (P > 0.385). IGF-1 was significantly related to BMC (beta = 0.920; P = 0.0001), total BMD (beta = 0.918; P = 0.0001), femoral neck BMD (beta = 0.921; P = 0.0001), and lumbar spine BMD (beta = 0.917; P = 0.0001), but did not remain significant when adjusted for fat free mass (FFM; P > 0.062). In addition, a significant association between IGF-1 and leptin was found (beta = 0.801; P = 0.0001), and it remained significant after controlling for age, FM, FFM, insulin, and fasting insulin resistance index (FIRI), but not when adjusted for BMC and body mass values. In conclusion, it appears that fasting IGF-1 and leptin concentrations have no direct effect on BMC and BMD values. In addition, if there is an important relationship between IGF-1 and leptin, it is mediated or confounded by BMC in premenopausal women.
本研究的目的是探讨血浆胰岛素样生长因子-1（IGF-1）和瘦素水平对绝经前女性骨矿物质含量（BMC）和骨矿物质密度（BMD）的影响，以及IGF-1与瘦素水平之间的关系。204名健康女性参与了本研究。所有参与者的体重指数（BMI）<30kg/m²，并根据其平均每日能量消耗水平进行匹配。BMC和BMD与测量的身体成分和血液生化参数相关。未观察到BMC和BMD值与测量的身体性能特征之间存在关联。瘦素与BMC（β=0.840；P=0.0001）、总BMD（β=0.833；P=0.0001）、股骨颈BMD（β=0.829；P=0.0001）和腰椎BMD（β=0.833；P=0.0001）有显著关联。然而，在调整体脂质量（FM）和躯干脂肪：腿部脂肪比率后，这些关联不再独立（P>0.385）。IGF-1与BMC（β=0.920；P=0.0001）、总BMD（β=0.918；P=0.0001）、股骨颈BMD（β=0.921；P=0.0001）和腰椎BMD（β=0.917；P=0.0001）显著相关，但在调整无脂肪质量（FFM；P>0.062）后不再显著。此外，发现IGF-1与瘦素之间存在显著关联（β=0.801；P=0.
