Jürimäe Jaak, Jürimäe Toivo, Leppik Aire, Kums Tatjana
Institute of Sport Pedagogy and Coaching Sciences, Centre of Behavioural and Health Sciences, University of Tartu, 18. Ulikooli St., Tartu, 50090, Estonia.
J Bone Miner Metab. 2008;26(6):618-23. doi: 10.1007/s00774-008-0861-5. Epub 2008 Nov 1.
The association of body fat mass (FM) with bone mineral mass (BMC) and bone mineral density (BMD) has been attributed to a mechanical load exerted on the skeleton by FM and by the effect of different hormones. The aim of the present study was to determine whether there is a relationship between ghrelin, adiponectin, and leptin with BMC and BMD in healthy postmenopausal women (n = 88; age, 68.9 +/- 6.8 years; body mass index, 27.4 +/- 3.6 kg/m(2)). Body composition, BMC, and BMD were derived by dual-energy X-ray absorptiometry. Waist-to-hip (WHR) and waist-to-thigh (WTR) ratios were also obtained. Ghrelin was associated with total BMC (beta = -0.945; P = 0.0001), total BMD (beta = -0.959; P = 0.0001), lumbar spine BMD (beta = -0.945; P = 0.0001), and femoral neck BMD (beta = -0.957; P = 0.0001), and remained associated (P < 0.041) in different analyses that controlled for measured body composition and hormonal and insulin resistance values. However, the associations between ghrelin and measured bone mineral values were no longer significant (P > 0.149) when adjusted for body fat distribution values (WHR, WTR). Adiponectin was significantly related to total BMC (beta = -0.931; P = 0.0001), total BMD (beta = -0.940; P = 0.0001), lumbar spine BMD (beta = -0.937; P = 0.0001), and femoral neck BMD (beta = -0.940; P = 0.0001) values, and these relationships remained significant (P < 0.019) after adjusting for measured body fat, hormonal, and insulin resistance values but not when adjusted for fat-free mass (FFM; P > 0.106). In addition, significant associations of leptin with total BMC (beta = 0.912; P = 0.0001), total BMD (beta = 0.907; P = 0.0001), lumbar spine BMD (beta = 0.899; P = 0.0001), and femoral neck BMD (beta = 0.906; P = 0.0001) were found. These associations remained significant (P < 0.010) in different analyses that controlled for hormonal and insulin resistance values, but the associations between leptin and bone mineral values were no longer significant (P > 0.145) when adjusted for specific body composition values (WHR, WTR, FM, and FFM). In conclusion, it appears that the influence of plasma ghrelin, adiponectin, and leptin levels on BMC and BMD values is mediated or confounded by the specific body composition parameters in healthy postmenopausal women.
体脂量（FM）与骨矿物质含量（BMC）和骨矿物质密度（BMD）之间的关联归因于FM对骨骼施加的机械负荷以及不同激素的作用。本研究的目的是确定在健康绝经后女性（n = 88；年龄，68.9±6.8岁；体重指数，27.4±3.6 kg/m²）中，胃饥饿素、脂联素和瘦素与BMC和BMD之间是否存在关系。通过双能X线吸收法得出身体成分、BMC和BMD。还获得了腰臀比（WHR）和腰大腿比（WTR）。胃饥饿素与总BMC（β = -0.945；P = 0.0001）、总BMD（β = -0.959；P = 0.0001）、腰椎BMD（β = -0.945；P = 0.0001）和股骨颈BMD（β = -0.957；P = 0.0001）相关，并且在控制了测量的身体成分以及激素和胰岛素抵抗值的不同分析中仍具有相关性（P < 0.041）。然而，当根据体脂分布值（WHR、WTR）进行调整时，胃饥饿素与测量的骨矿物质值之间的关联不再显著（P > 0.149）。脂联素与总BMC（β = -0.931；P = 0.0001）、总BMD（β = -0.940；P = 0.0001）、腰椎BMD（β = -0.937；P = 0.0001）和股骨颈BMD（β = -0.940；P = 0.0001）值显著相关，在调整了测量的体脂、激素和胰岛素抵抗值后，这些关系仍然显著（P < 0.019），但在根据去脂体重（FFM；P > 0.106）进行调整时则不然。此外，发现瘦素与总BMC（β = 0.912；P = 0.0001）、总BMD（β = 0.907；P = 0.0001）、腰椎BMD（β = 0.899；P = 0.0001）和股骨颈BMD（β = 0.906；P = 0.0001）有显著关联。在控制了激素和胰岛素抵抗值的不同分析中，这些关联仍然显著（P < 0.010），但当根据特定的身体成分值（WHR、WTR、FM和FFM）进行调整时，瘦素与骨矿物质值之间的关联不再显著（P > 0.145）。总之，在健康绝经后女性中，血浆胃饥饿素、脂联素和瘦素水平对BMC和BMD值的影响似乎是由特定的身体成分参数介导或混淆的。
