Jürimäe J, Jürimäe T
Institute of Sport Pedagogy and Coaching Sciences, Centre of Behavioural and Health Sciences, University of Tartu, 18. Ulikooli St., Tartu, 50090, Estonia.
Osteoporos Int. 2007 Sep;18(9):1253-9. doi: 10.1007/s00198-007-0365-5. Epub 2007 Mar 30.
Adipose-modulated biochemical signal that explains some of the association between fat mass and bone mineral density (BMD) is adiponectin. The results demonstrated an independent association between adiponectin and BMD, while the influence of adiponectin on bone mineral content is mediated by fat free mass in middle-aged women.
Positive association between fat mass (FM) and bone mineral density (BMD) is mediated by biochemical factors.
The relationship between plasma adiponectin concentration and BMD in 98 sedentary premenopausal women aged 38-49 years with a body mass index range of 20.0-42.1 kg/m(2) was examined. Different body composition and blood biochemical parameters were measured to adjust for possible confounding variables.
The association between adiponectin and BMD values (total BMD: beta = -0.919; p = 0.0001, femoral neck BMD: beta = -0.925; p = 0.0001 and lumbar spine BMD: ss = -0.912; p = 0.0001) was independent of the influences that measured body composition, hormonal and insulin resistance factors may exert on BMD (p < 0.02). However, adiponectin explained only 3-12% of the variations in measured BMD variables. Similarly, adiponectin was associated with total bone mineral content (BMC; beta = -0.911; p = 0.0001) and remained associated in different analyses that controlled for possible confounding parameters (p < 0.01). However, the association between adiponectin and total BMC was no longer significant when adjusted for fat free mass (FFM; p > 0.21).
Adiponectin is an independent predictor of BMD, while its independent contribution to the interindividual variance in measured values is only modest. The influence of adiponectin on total BMC is mediated or confounded by FFM in middle-aged premenopausal women.
脂联素是一种脂肪调节的生化信号，它解释了脂肪量与骨矿物质密度（BMD）之间的部分关联。结果表明脂联素与BMD之间存在独立关联，而在中年女性中，脂联素对骨矿物质含量的影响是由去脂体重介导的。
脂肪量（FM）与骨矿物质密度（BMD）之间的正相关是由生化因素介导的。
研究了98名年龄在38 - 49岁、体重指数范围为20.0 - 42.1 kg/m²的久坐未绝经女性血浆脂联素浓度与BMD之间的关系。测量了不同的身体成分和血液生化参数，以调整可能的混杂变量。
脂联素与BMD值（总BMD：β = -0.919；p = 0.0001，股骨颈BMD：β = -0.925；p = 0.0001，腰椎BMD：β = -0.912；p = 0.0001）之间的关联独立于所测量的身体成分、激素和胰岛素抵抗因素可能对BMD产生的影响（p < 0.02）。然而，脂联素仅解释了所测量的BMD变量中3 - 12%的变异。同样，脂联素与总骨矿物质含量（BMC；β = -0.911；p = 0.0001）相关，并且在控制了可能的混杂参数的不同分析中仍然相关（p < 0.01）。然而，当调整去脂体重（FFM）后，脂联素与总BMC之间的关联不再显著（p > 0.21）。
脂联素是BMD的独立预测因子，但其对测量值个体间差异的独立贡献较小。在中年未绝经女性中，脂联素对总BMC的影响由FFM介导或受其混杂。
