Jürimäe Jaak, Kums Tatjana, Jürimäe Toivo
Institute of Sport Pedagogy and Coaching Sciences Institute of Exercise Physiology and Physiotherapy, Centre of Behavioural and Health Sciences, University of Tartu, Tartu, Estonia.
Eur J Endocrinol. 2009 Mar;160(3):381-5. doi: 10.1530/EJE-08-0673. Epub 2008 Dec 3.
We investigated the relationship between the decrease in bone mineral mass (BMC) and bone mineral density (BMD) values with baseline adipocytokine and ghrelin concentrations in physically active postmenopausal women.
Leptin, adiponectin, ghrelin, BMC, BMD and different body composition values were measured in 35 women (age: 69.7+/-6.0 years) before and after a 12-month prospective study period.
Significant (P<0.05) decreases in fat-free mass (FFM) (by 2.56%) and BMC (by 1.63%) and increases in adiponectin (by 14.8%) were seen in older females as a result of the study period. The independent variables that were associated with decreases in total BMC were baseline fat mass (FM) and adiponectin explaining 30.6% (R(2)x100) of the total variance. In another model, baseline FFM and leptin were the independent variables that explained 20.6% (P<0.05) of the total variance in the decreases in total BMD value. The variables that were associated with decreases in femoral neck BMD were FM and leptin (R(2)=0.102; P<0.05), while the independent variables were baseline trunk fat:leg fat ratio and adiponectin in the model with decreases in lumbar spine BMD as the dependent variable, and accounted for 13.1% (P<0.05) of the decreases in BMD variance.
Initial adiponectin concentration together with specific body composition characteristics predicted loss in BMC and lumbar spine BMD values, while initial leptin concentration together with specific body composition parameters determined the loss in total and femoral neck BMD values in physically active older women.
我们研究了身体活跃的绝经后女性骨矿物质质量（BMC）和骨矿物质密度（BMD）值的下降与基线脂肪细胞因子和胃饥饿素浓度之间的关系。
在一项为期12个月的前瞻性研究前后，对35名女性（年龄：69.7±6.0岁）测量了瘦素、脂联素、胃饥饿素、BMC、BMD和不同的身体成分值。
经过研究期，老年女性的去脂体重（FFM）显著下降（2.56%），BMC显著下降（1.63%），脂联素增加（14.8%）（P<0.05）。与总BMC下降相关的自变量是基线脂肪量（FM）和脂联素，它们解释了总方差的30.6%（R²×100）。在另一个模型中，基线FFM和瘦素是自变量，它们解释了总BMD值下降中总方差的20.6%（P<0.05）。与股骨颈BMD下降相关的变量是FM和瘦素（R²=0.102；P<0.05），而在以腰椎BMD下降为因变量的模型中，自变量是基线躯干脂肪：腿部脂肪比率和脂联素，它们占BMD方差下降的13.1%（P<0.05）。
初始脂联素浓度与特定的身体成分特征共同预测了BMC和腰椎BMD值的损失，而初始瘦素浓度与特定的身体成分参数共同决定了身体活跃的老年女性总BMD和股骨颈BMD值的损失。
