Christou Nicolas V, Look Didier, Maclean Lloyd D
Section of Bariatric Surgery, Division of General Surgery, McGill University Health Center, Montreal, Quebec, Canada.
Ann Surg. 2006 Nov;244(5):734-40. doi: 10.1097/01.sla.0000217592.04061.d5.
To complete a long-term (>10 years) follow-up of patients undergoing isolated roux-en-Y gastric bypass for severe obesity.
Long-term results of gastric bypass in patients followed for longer than 10 years is not reported in the literature.
Accurate weights were recorded on 228 of 272 (83.8%) of patients at a mean of 11.4 years (range, 4.7-14.9 years) after surgery. Results were documented on an individual basis for both long- and short-limb gastric bypass and compared with results at the nadir BMI and % excess weight loss (%EWL) at 5 years and >10 years post surgery.
There was a significant (P < 0.0001) increase in BMI in both morbidly obese (BMI < 50 kg/m) and super obese patients (BMI > 50 kg/m) from the nadir to 5 years and from 5 to 10 years. The super obese lost more rapidly from time zero and gained more rapidly after reaching the lowest weight at approximately 2 years than the morbidly obese patients. There was no difference in results between the long- and short-limb operations. There was a significant increase in failures and decrease in excellent results at 10 years when compared with 5 years. The failure rate when all patients are followed for at least 10 years was 20.4% for morbidly obese patients and 34.9% for super obese patients.
The gastric bypass limb length does not impact long-term weight loss. Significant weight gain occurs continuously in patients after reaching the nadir weight following gastric bypass. Despite this weight gain, the long-term mortality remains low at 3.1%.
对接受单纯Roux-en-Y胃旁路手术治疗重度肥胖的患者进行长期(>10年)随访。
文献中未报道胃旁路手术患者超过10年的长期结果。
对272例患者中的228例(83.8%)进行了准确体重记录,时间为术后平均11.4年(范围4.7 - 14.9年)。记录了长肢和短肢胃旁路手术患者的个体结果,并与术后5年和>10年时的最低体重指数(BMI)及超重减轻百分比(%EWL)结果进行比较。
从最低点到5年以及从5年到10年,病态肥胖(BMI<50 kg/m²)和超级肥胖患者(BMI>50 kg/m²)的BMI均显著增加(P<0.0001)。超级肥胖患者从零时起体重下降更快,在约2年达到最低体重后体重增加也比病态肥胖患者更快。长肢和短肢手术的结果没有差异。与5年相比,10年时失败率显著增加,优秀结果减少。当所有患者至少随访10年时,病态肥胖患者的失败率为20.4%,超级肥胖患者为34.9%。
胃旁路手术的肢体长度不影响长期体重减轻。胃旁路手术后患者达到最低体重后体重持续显著增加。尽管体重增加,但长期死亡率仍较低,为3.1%。