Bazarah Salem M, Ritenour Rusty, Patel Sunil T, Hirsch Geri, Peltekian Kevork M, Cruess Alan F
Hepatology Services, Division of Gastroenterology, Dalhousie University, and Capital District Health Authority, Halifax, Nova Scotia, Canada.
Ann Hepatol. 2006 Jul-Sep;5(3):172-6.
We report a case of new interferon-associated ocular complication during treatment with combination of pegylated interferon plus ribavirin for chronic hepatitis C infection. Our patient developed choroidal neovascularization in addition to the classic interferon associated retinopathy. Choroidal neovascularization has not been reported before in association with interferon induced retinopathy. We describe our management to control the ocular symptoms and the retinal lesions with one year follow up. We also provide literature report on the natural history, the pathophysiology and the variable characteristics of interferon associated retinopathy versus hepatitis C related ophthalmopathy.
我们报告了1例在使用聚乙二醇化干扰素联合利巴韦林治疗慢性丙型肝炎感染期间出现的新型干扰素相关眼部并发症。我们的患者除了出现典型的干扰素相关性视网膜病变外,还发生了脉络膜新生血管形成。此前尚未有关于脉络膜新生血管形成与干扰素诱导性视网膜病变相关的报道。我们描述了在1年随访期间控制眼部症状和视网膜病变的治疗方法。我们还提供了关于干扰素相关性视网膜病变与丙型肝炎相关眼病的自然病史、病理生理学及不同特征的文献报道。