细胞信号通路的物理化学建模

Physicochemical modelling of cell signalling pathways.

作者信息

Aldridge Bree B, Burke John M, Lauffenburger Douglas A, Sorger Peter K

机构信息

Center for Cell Decision Processes, Department Biological Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

出版信息

Nat Cell Biol. 2006 Nov;8(11):1195-203. doi: 10.1038/ncb1497.

DOI:10.1038/ncb1497

PMID:17060902

Abstract

Physicochemical modelling of signal transduction links fundamental chemical and physical principles, prior knowledge about regulatory pathways, and experimental data of various types to create powerful tools for formalizing and extending traditional molecular and cellular biology.

摘要

信号转导的物理化学建模将基础化学和物理原理、关于调控途径的先验知识以及各种类型的实验数据结合起来，以创建强大的工具，用于形式化和扩展传统的分子与细胞生物学。