Xu W-H, Dai Q, Xiang Y-B, Zhao G-M, Zheng W, Gao Y-T, Ruan Z-X, Cheng J-R, Shu X-O
Department of Epidemiology, Shanghai Cancer Institute, 2200/25 Xie Tu Road, Shanghai 200032, China.
Br J Cancer. 2006 Dec 4;95(11):1586-92. doi: 10.1038/sj.bjc.6603458. Epub 2006 Oct 24.
We evaluated animal food intake and cooking methods in relation to endometrial cancer risk in a population-based case-control study in Shanghai, China. A validated food frequency questionnaire was used to collect the usual dietary habits of 1204 cases and 1212 controls aged 30-69 years between 1997 and 2003. Statistical analyses were based on an unconditional logistic regression model adjusting for potential confounders. High intake of meat and fish was associated with an increased risk of endometrial cancer, with adjusted odds ratios for the highest vs the lowest quartile groups being 1.7 (95% confidence interval: 1.3-2.2) and 2.4 (1.8-3.1), respectively. The elevated risk was observed for all types of meat and fish intake. Intake of eggs and milk was not related to risk. Cooking methods and doneness levels for meat and fish were not associated with risk, nor did they modify the association with meat and fish consumption. Our study suggests that animal food consumption may play an important role in the aetiology of endometrial cancer, but cooking methods have minimal influence on risk among Chinese women.
在中国上海开展的一项基于人群的病例对照研究中，我们评估了动物类食物摄入量及烹饪方法与子宫内膜癌风险之间的关系。采用一份经过验证的食物频率问卷，收集了1997年至2003年间1204例年龄在30 - 69岁的病例及1212例对照的日常饮食习惯。统计分析基于无条件逻辑回归模型，并对潜在混杂因素进行了校正。肉类和鱼类的高摄入量与子宫内膜癌风险增加相关，最高四分位数组与最低四分位数组相比，校正后的比值比分别为1.7（95%置信区间：1.3 - 2.2）和2.4（1.8 - 3.1）。各类肉类和鱼类摄入量均呈现风险升高。蛋类和奶类的摄入量与风险无关。肉类和鱼类的烹饪方法及熟度水平与风险无关，也未改变其与肉类和鱼类消费的关联。我们的研究表明，动物类食物消费可能在子宫内膜癌病因学中发挥重要作用，但烹饪方法对中国女性的风险影响极小。
