Zinaman Michael J
Department of Obstetrics and Gynecology, Loyola University of Chicago, IL, USA.
Paediatr Perinat Epidemiol. 2006 Nov;20 Suppl 1:26-9. doi: 10.1111/j.1365-3016.2006.00767.x.
To help fulfil the objectives of prospective studies of pregnancy and human development, such as the National Children's Study, there is a need to pinpoint ovulation and conception in a cohort of women. This paper discusses the suitability of using natural and easily observed markers of ovulation for detection of the most likely day of ovulation and conception. Of the biomarkers supported by clinical data, the use of cervical mucus is emphasised as it appears most promising. A considerable amount of data suggests that observation of changes in vaginal discharge from cervical mucus can closely approximate the day of ovulation, is easy to learn and suitable for a large group of women. While this approach could also be cost-effective, a significant drawback may be the learning phase which may take 2-3 instructional sessions for women to fully identify recurring changes across the menstrual cycle.
为帮助实现诸如国家儿童研究等关于妊娠和人类发育的前瞻性研究目标，有必要在一群女性中精准确定排卵和受孕时间。本文讨论了使用自然且易于观察的排卵标志物来检测最有可能排卵和受孕日期的适用性。在临床数据支持的生物标志物中，宫颈黏液的使用受到重视，因为它似乎最具前景。大量数据表明，观察宫颈黏液导致的阴道分泌物变化能够非常接近排卵日，易于掌握且适用于广大女性群体。虽然这种方法可能具有成本效益，但一个显著缺点可能是学习阶段，女性可能需要2至3次指导课程才能完全识别整个月经周期中反复出现的变化。
