Holvik Kristin, Meyer Haakon E, Søgaard Anne Johanne, Selmer Randi, Haug Egil, Falch Jan A
Institute of General Practice and Community Medicine, University of Oslo, PO Box 1130 Blindern, N-0318 Oslo, Norway, Division of Epidemiology, Norwegian Institute of Public Health, Oslo, Norway.
Eur J Endocrinol. 2006 Nov;155(5):693-9. doi: 10.1530/eje.1.02282.
To evaluate whether Pakistanis have increased bone turnover compared with ethnic Norwegians due to their high prevalence of vitamin D deficiency and secondary hyperparathyroidism, and whether the relation between bone turnover and bone mineral density (BMD) differs between Pakistanis and ethnic Norwegians.
A cross-sectional, population-based study conducted in the city of Oslo in 2000-2001. Random samples of 132 community-dwelling Pakistani men and women of ages 40, 45, and 59-60 years, and 580 community-dwelling Norwegian men and women of ages 45 and 59-60 years are included in this substudy.
Venous serum samples were drawn for measurements of markers of the vitamin D endocrine system and the bone turnover markers osteocalcin (s-OC), bone alkaline phosphatase (s-bone ALP), and tartrate-resistant acid phosphatase (s-TRACP). BMD was measured at the forearm by single-energy X-ray absorptiometry.
Pakistanis had higher s-bone ALP compared with Norwegians. Mean (95% CI) age-adjusted levels were 22.5 (21.0, 24.1) U/l in Pakistani men versus 19.3 (18.6, 20.1) U/l in Norwegian men, P < 0.0005, and 20.3 (18.4, 22.1) U/l in Pakistani women versus 16.7 (16.0, 17.4) U/l in Norwegian women, P = 0.001. There tended to be an inverse association between bone turnover and BMD in men and women of both ethnic groups, and it was strongest for s-bone ALP. Overall mean (95% CI) distal BMD decrease was -16 (-20, -11) mg/cm(2) per 1 s.d. increase in s-bone ALP (P < 0.0005) when adjusting for age, sex, and ethnicity.
Except for somewhat higher s-bone ALP levels in Pakistanis, there were only minor ethnic differences in bone turnover, despite a strikingly different prevalence of secondary hyperparathyroidism. Bone turnover was inversely associated with forearm BMD in both ethnic groups.
评估由于维生素D缺乏和继发性甲状旁腺功能亢进的高患病率，巴基斯坦人与挪威种族相比是否具有更高的骨转换率，以及巴基斯坦人和挪威种族之间骨转换与骨矿物质密度（BMD）的关系是否不同。
2000 - 2001年在奥斯陆市进行的一项基于人群的横断面研究。该子研究纳入了年龄为40、45以及59 - 60岁的132名居住在社区的巴基斯坦男性和女性，以及年龄为45和59 - 60岁的580名居住在社区的挪威男性和女性的随机样本。
采集静脉血清样本以测量维生素D内分泌系统标志物以及骨转换标志物骨钙素（s - OC）、骨碱性磷酸酶（s - bone ALP）和抗酒石酸酸性磷酸酶（s - TRACP）。通过单能X线吸收法测量前臂的骨密度。
与挪威人相比，巴基斯坦人的s - bone ALP更高。在年龄调整后的水平中，巴基斯坦男性的平均（95%置信区间）为22.5（21.0, 24.1）U/l，而挪威男性为19.3（18.6, 20.1）U/l，P < 0.0005；巴基斯坦女性为20.3（18.4, 22.1）U/l，而挪威女性为16.7（16.0, 17.4）U/l，P = 0.001。在两个种族的男性和女性中，骨转换与骨密度之间均存在负相关，且以s - bone ALP最为显著。在调整年龄、性别和种族后，s - bone ALP每增加1个标准差，总体平均（95%置信区间）远端骨密度下降为 - 16（- 20, - 11）mg/cm²（P < 0.0005）。
除了巴基斯坦人的s - bone ALP水平略高外，尽管继发性甲状旁腺功能亢进的患病率存在显著差异，但骨转换方面的种族差异较小。在两个种族中，骨转换均与前臂骨密度呈负相关。
