Brunvand L, Haug E
Pediatric Department, Ullevål Hospital, Oslo, Norway.
Acta Obstet Gynecol Scand. 1993 May;72(4):264-8. doi: 10.3109/00016349309068035.
To evaluate the vitamin D status in pregnant Pakistani women living in Oslo, we measured levels of serum calcidiol, calcitriol, vitamin D binding protein (DBP), osteocalcin, free calcium (Ca2+), phosphorous, alkaline phosphatase and intact parathyroid hormone (PTH). Thirty Pakistani and 23 Norwegian women who delivered vaginally after uncomplicated pregnancies were included. The serum levels of calcidiol were significantly lower in the Pakistani group (p < 0.0001) as compared with the Norwegians, the mean values being 15.1 nmol/l and 43.1 nmol/l, respectively. PTH levels were above 5.5 pmol/l in 13 of the Pakistanis, none of the Norwegians. There were no differences in calculated free calcitriol, free calcium and inorganic phosphorus between the groups. Alkaline phosphatase was high, while osteocalcin was low in both groups, but there were no significant differences between the groups. This study shows that there is a widespread vitamin D deficiency amongst pregnant Pakistani women living in Oslo, indicating the need for vitamin D supplementation to these women and their children.
为评估居住在奥斯陆的巴基斯坦孕妇的维生素D状况,我们检测了血清骨化二醇、骨化三醇、维生素D结合蛋白(DBP)、骨钙素、游离钙(Ca2+)、磷、碱性磷酸酶和完整甲状旁腺激素(PTH)的水平。纳入了30名巴基斯坦妇女和23名挪威妇女,她们均经历了无并发症的妊娠并顺产。与挪威妇女相比,巴基斯坦组的血清骨化二醇水平显著更低(p < 0.0001),平均值分别为15.1 nmol/l和43.1 nmol/l。13名巴基斯坦妇女的PTH水平高于5.5 pmol/l,而挪威妇女中无人如此。两组之间计算得出的游离骨化三醇、游离钙和无机磷并无差异。两组的碱性磷酸酶均较高,而骨钙素均较低,但两组之间无显著差异。本研究表明,居住在奥斯陆的巴基斯坦孕妇中普遍存在维生素D缺乏,这表明需要对这些妇女及其子女补充维生素D。