Simpson R H, Sarsfield P T, Clarke T, Babajews A V
Postgraduate Medical School, University of Exeter, UK.
Histopathology. 1990 Nov;17(5):433-8. doi: 10.1111/j.1365-2559.1990.tb00764.x.
Two cases of carcinoma of the minor salivary glands are presented in which most cells had clear cytoplasm. Both patients had clinical histories in excess of 10 years and, in the one case with adequate follow-up, no recurrence had occurred after a further 11 years. Both tumours were locally invasive. The clear cells contained small amounts of glycogen, but no intracytoplasmic mucin. Immunohistochemical and ultrastructural studies showed epithelial features, with no evidence of myoepithelial differentiation. These tumours were very similar to the small number of previously reported cases, which were all considered to be low-grade carcinomas. Amongst the differential diagnoses, the most important is metastatic clear cell carcinoma of the kidney and this can only be confidently excluded clinically or by the use of imaging techniques. In summary, we consider intraoral clear cell carcinoma to be a distinct tumour of low malignant potential.
本文报告两例小唾液腺癌，其中大多数细胞具有透明细胞质。两名患者的临床病史均超过10年，其中一例随访充分，在接下来的11年中未出现复发。两个肿瘤均有局部浸润性。透明细胞含有少量糖原，但无胞浆内黏液。免疫组织化学和超微结构研究显示为上皮特征，无肌上皮分化证据。这些肿瘤与先前报道的少数病例非常相似，均被认为是低级别癌。在鉴别诊断中，最重要的是肾转移性透明细胞癌，这只能通过临床或影像学技术可靠地排除。总之，我们认为口腔内透明细胞癌是一种具有低恶性潜能的独特肿瘤。
